Increased extracellular matrix deposition during chondrogenic differentiation of dental pulp stem cells from individuals with neurofibromatosis type 1: an in vitro 2D and 3D study

• Published in: Orphanet journal of rare diseases Vol. 13; no. 1; p. 98
• Main Authors: Almeida, Paula Nascimento, Barboza, Deuilton do Nascimento, Luna, Eloá Borges, Correia, Maria Clara de Macena, Dias, Rhayra Braga, Siquara de Sousa, Ana Caroline, Duarte, Maria Eugenia Leite, Rossi, Maria Isabel Doria, Cunha, Karin Soares
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 25.06.2018; BioMed Central; BMC
• Subjects: Adipogenesis - physiology; Adult; Analysis; Bone marrow; Care and treatment; Cartilage cells; Cell culture; Cell differentiation; Cell Differentiation - genetics; Cell Differentiation - physiology; Cells, Cultured; Chondrogenesis; Chondrogenesis - genetics; Chondrogenesis - physiology; Dental pulp; Dental Pulp - cytology; Development and progression; Extracellular matrix; Female; Genetic disorders; Health aspects; Humans; Male; Medical research; Metabolic pathways; Microscopy; Mutation; Neurofibromatosis; Neurofibromatosis 1; Neurofibromatosis 1 - metabolism; Neurological disorders; Pathogenesis; Physiological aspects; Rare diseases; Recklinghausen's disease; Stem cells; Stem Cells - cytology; Stem Cells - metabolism; Tumors; Young Adult; United States > US; Cell culture; Neurofibromatosis 1; Cell differentiation; Chondrogenesis

Neurofibromatosis 1 (NF1) presents a wide range of clinical manifestations, including bone alterations. Studies that seek to understand cellular and molecular mechanisms underlying NF1 orthopedic problems are of great importance to better understand the pathogenesis and the development of new therap...