Spectrum and clinical features of gene mutations in Chinese pediatric acute lymphoblastic leukemia

• Published in: BMC pediatrics Vol. 23; no. 1; p. 62
• Main Authors: Shen, Diying, Liu, Lixia, Xu, Xiaojun, Song, Hua, Zhang, Jingying, Xu, Weiqun, Zhao, Fenying, Liang, Juan, Liao, Chan, Wang, Yan, Xia, Tian, Wang, Chengcheng, Lou, Feng, Cao, Shanbo, Qin, Jiayue, Tang, Yongmin
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 04.02.2023; BioMed Central; BMC
• Subjects: Acute lymphoblastic leukemia; Acute lymphocytic leukemia; Analysis; Bone marrow; Cerebrospinal fluid; Child; Children; Clinical features; Correlations; Cytogenetics; Diagnosis; Diseases; DNA methylation; East Asian People; Gene mutations; Genes; Genetic aspects; Genomes; Genomics; Hemoglobin; Humans; Infant; Leukemia; Medical prognosis; Mutation; Next-generation sequencing; Patients; Pediatrics; Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics; Prognosis; Software; Transcription Factors - genetics; China; Clinical features; Next-generation sequencing; Acute lymphoblastic leukemia; Gene mutations; Correlations

The 5-year survival rate of children with acute lymphoblastic leukemia (ALL) is 85-90%, with a 10-15% rate of treatment failure. Next-generation sequencing (NGS) identified recurrent mutated genes in ALL that might alter the diagnosis, classification, prognostic stratification, treatment, and respon...