Tumor cell-derived SPON2 promotes M2-polarized tumor-associated macrophage infiltration and cancer progression by activating PYK2 in CRC

• Published in: Journal of experimental & clinical cancer research Vol. 40; no. 1; pp. 304 - 17
• Main Authors: Huang, Chengmei, Ou, Ruizhang, Chen, Xiaoning, Zhang, Yaxin, Li, Jiexi, Liang, Yihao, Zhu, Xiaohui, Liu, Lei, Li, Mingzhou, Lin, Dagui, Qiu, Junfeng, Liu, Guanglong, Zhang, Lingjie, Wu, Yuanyuan, Tang, Huiyi, Liu, Yanmin, Liang, Li, Ding, Yanqing, Liao, Wenting
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 28.09.2021; BioMed Central; BMC
• Subjects: Animals; Antibodies; Apoptosis; Biomarkers, Tumor - genetics; Biomarkers, Tumor - metabolism; Bone marrow; Cell Proliferation; Colorectal cancer; Colorectal Neoplasms - immunology; Colorectal Neoplasms - metabolism; Colorectal Neoplasms - pathology; Cytokines; Development and progression; Extracellular Matrix Proteins - genetics; Extracellular Matrix Proteins - metabolism; Female; Focal Adhesion Kinase 2 - genetics; Focal Adhesion Kinase 2 - metabolism; Gene expression; Gene Expression Regulation, Neoplastic; Genotype & phenotype; Humans; Integrins; Invasion; Liver cancer; Liver Neoplasms - immunology; Liver Neoplasms - metabolism; Liver Neoplasms - secondary; Macrophages; Medical prognosis; Metastasis; Mice; Mice, Inbred C57BL; Neoplasm Proteins - genetics; Neoplasm Proteins - metabolism; Plasmids; Prognosis; Prostate cancer; PYK2; SPON2; Survival Rate; Tumor Cells, Cultured; Tumor-associated macrophages; Tumor-Associated Macrophages - immunology; Tumors; Xenograft Model Antitumor Assays; United States > US; SPON2; Metastasis; PYK2; Invasion; Tumor-associated macrophages; Colorectal cancer

Tumor-associated macrophages (TAMs) are key regulators of the complex interplay between cancer and the immune microenvironment. Tumor cell-derived spondin 2 (SPON2) is an extracellular matrix glycoprotein that has complicated roles in recruitment of macrophages and neutrophils during inflammation. O...