Single-cell genomic and transcriptomic landscapes of primary and metastatic colorectal cancer tumors

• Published in: Genome medicine Vol. 14; no. 1; pp. 93 - 26
• Main Authors: Wang, Rui, Li, Jingyun, Zhou, Xin, Mao, Yunuo, Wang, Wendong, Gao, Shuai, Wang, Wei, Gao, Yuan, Chen, Kexuan, Yu, Shuntai, Wu, Xinglong, Wen, Lu, Ge, Hao, Fu, Wei, Tang, Fuchou
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 16.08.2022; BioMed Central; BMC
• Subjects: Apoptosis; Cancer; Cell differentiation; Cell self-renewal; Colorectal cancer; Colorectal carcinoma; Colorectal Neoplasms - genetics; Colorectal Neoplasms - pathology; Copy number; DNA Copy Number Variations; DNA sequencing; DNA, Complementary; Gene expression; Gene mutations; Genetic aspects; Genomes; Genomics; Genotype-phenotype relationship; Health aspects; Humans; Lineage tracing; Liver; Lymph nodes; Lymphatic system; Metastases; Metastasis; Metastatic colorectal cancer; Microscopy; Mitochondria; Mitochondrial mutations; Mutation; Neoplasm Metastasis; Nucleotide sequencing; Oncology, Experimental; Organoids; Patient-derived organoids; Patients; Peroxisome proliferator-activated receptors; Peroxisome Proliferator-Activated Receptors - antagonists & inhibitors; Peroxisome Proliferator-Activated Receptors - genetics; Point mutation; Ribonucleic acid; RNA; RNA sequencing; Signal transduction; Single-cell transcriptome profiling; Stem cells; Therapeutic targets; Transcriptome; Transcriptomics; Tumor cells; Tumor proteins; Tumorigenesis; Tumors; Whole genome sequencing; Genotype-phenotype relationship; Patient-derived organoids; Mitochondrial mutations; Lineage tracing; Single-cell transcriptome profiling; Metastatic colorectal cancer; PPAR signaling pathway

Colorectal cancer (CRC) ranks as the second-leading cause of cancer-related death worldwide with metastases being the main cause of cancer-related death. Here, we investigated the genomic and transcriptomic alterations in matching adjacent normal tissues, primary tumors, and metastatic tumors of CRC...