Single-cell genomic and transcriptomic landscapes of primary and metastatic colorectal cancer tumors - Wang, Rui; Li, Jingyun; Zhou, Xin; Mao, Yunuo; Wang, Wendong; Gao, Shuai; Wang, Wei; Gao, Yuan; Chen, Kexuan; Yu, Shuntai; Wu, Xinglong; Wen, Lu; et al. (Genome medicine, 2022)
Keywords: Apoptosis; Cancer; Cell differentiation; Cell self-renewal; Colorectal cancer; Colorectal carcinoma; Colorectal Neoplasms - genetics; Colorectal Neoplasms - pathology; Copy number; DNA Copy Number Variations; DNA sequencing; DNA, Complementary; Gene expression; Gene mutations; Genetic aspects; Genomes; Genomics; Genotype-phenotype relationship; Health aspects; Humans; Lineage tracing; Liver; Lymph nodes; Lymphatic system; Metastases; Metastasis; Metastatic colorectal cancer; Microscopy; Mitochondria; Mitochondrial mutations; Mutation; Neoplasm Metastasis; Nucleotide sequencing; Oncology, Experimental; Organoids; Patient-derived organoids; Patients; Peroxisome proliferator-activated receptors; Peroxisome Proliferator-Activated Receptors - antagonists & inhibitors; Peroxisome Proliferator-Activated Receptors - genetics; Point mutation; Ribonucleic acid; RNA; RNA sequencing; Signal transduction; Single-cell transcriptome profiling; Stem cells; Therapeutic targets; Transcriptome; Transcriptomics; Tumor cells; Tumor proteins; Tumorigenesis; Tumors; Whole genome sequencing; Genotype-phenotype relationship; Patient-derived organoids; Mitochondrial mutations; Lineage tracing; Single-cell transcriptome profiling; Metastatic colorectal cancer; PPAR signaling pathway