Dipeptidyl Peptidase 4: A New Link between Diabetes Mellitus and Atherosclerosis?

• Published in: BioMed research international Vol. 2015; no. 2015; pp. 1 - 10
• Main Authors: Silva Junior, Wellington Santana da, Godoy-Matos, Amelio Fernando de, Kraemer-Aguiar, Luiz Guilherme
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2015; John Wiley & Sons, Inc; Hindawi Limited
• Subjects: Atherosclerosis; Atherosclerosis - complications; Atherosclerosis - drug therapy; Atherosclerosis - metabolism; Bioavailability; Cell adhesion & migration; Clinical trials; Confidence intervals; Diabetes; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - drug therapy; Diabetes Mellitus, Type 2 - metabolism; Dipeptidyl Peptidase 4 - genetics; Dipeptidyl Peptidase 4 - metabolism; Dipeptidyl-Peptidase IV Inhibitors - therapeutic use; Endocrinology; Enzymes; Gangrene; Glucose; Health aspects; Humans; Incretins - metabolism; Inflammation - drug therapy; Inflammation - metabolism; Inflammation - pathology; Insulin; Insulin resistance; Physiological aspects; Polypeptides; Proteases; Proteins; Review; Studies

Type 2 diabetes mellitus (T2DM) has become one of the most prevalent noncommunicable diseases in the past years. It is undoubtedly associated with atherosclerosis and increased risk for cardiovascular diseases. Incretins, which are intestinal peptides secreted during digestion, are able to increase...