Optical biomarkers for breast cancer derived from dynamic diffuse optical tomography

• Published in: Journal of biomedical optics Vol. 18; no. 9; p. 096012
• Main Authors: Flexman, Molly L, Kim, Hyun K, Gunther, Jacqueline E, Lim, Emerson A, Alvarez, Maria C, Desperito, Elise, Kalinsky, Kevin, Hershman, Dawn L, Hielscher, Andreas H
• Format: Journal Article
• Language: English
• Published: United States Society of Photo-Optical Instrumentation Engineers 01.09.2013
• Subjects: Adult; Biomarkers, Tumor - blood; Biomarkers, Tumor - chemistry; Breast; Breast Neoplasms - blood supply; Breast Neoplasms - chemistry; Breast Neoplasms - physiopathology; Breath Holding; Cancer; Diffusion; Dynamic tests; Dynamical systems; Dynamics; Female; Hemodynamics - physiology; Hemoglobins - analysis; Humans; Imaging; Imaging, Three-Dimensional - methods; Middle Aged; Oxyhemoglobins - analysis; Tomography; Tomography, Optical - methods; breast cancer; dynamic optical imaging; optical breast imaging; diffuse optical tomography; digital diffuse optical imaging

Diffuse optical tomography (DOT) is a noninvasive, nonionizing imaging modality that uses near-infrared light to visualize optically relevant chromophores. A recently developed dynamic DOT imaging system enables the study of hemodynamic effects in the breast during a breath-hold. Dynamic DOT imaging...