Comparative study of two protocols for quantitative image-analysis of serotonin transporter clustering in lymphocytes, a putative biomarker of therapeutic efficacy in major depression

• Published in: Biomarker research Vol. 5; no. 1; pp. 27 - 8
• Main Authors: Romay-Tallon, Raquel, Rivera-Baltanas, Tania, Allen, Josh, Olivares, Jose M., Kalynchuk, Lisa E., Caruncho, Hector J.
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 22.09.2017; BioMed Central; BMC
• Subjects: Antibodies; Biomarkers; Blood smears; Care and treatment; Committees; Data processing; Depression; Depression (Mood disorder); Development and progression; Ethics; Experiments; Genetic aspects; Health aspects; Image processing; Innovations; Lipids; Lymphocytes; Membrane protein clustering; Membrane proteins; Mental depression; Methodology; Molecular diagnostic techniques; Physiology; Proteins; Psychological aspects; Serotonin; Serotonin transporter; Transport proteins; Biomarkers; Blood smears; Depression; Serotonin transporter; Membrane protein clustering; Lymphocytes

The pattern of serotonin transporter clustering on the plasma membrane of lymphocytes extracted from human whole blood samples has been identified as a putative biomarker of therapeutic efficacy in major depression. Here we evaluated the possibility of performing a similar analysis using blood smear...