New insights into the role of TREM2 in Alzheimer’s disease

• Published in: Molecular neurodegeneration Vol. 13; no. 1; pp. 66 - 16
• Main Authors: Gratuze, Maud, Leyns, Cheryl E. G., Holtzman, David M.
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 20.12.2018; BioMed Central; BMC
• Subjects: Alzheimer Disease - metabolism; Alzheimer's disease; Amyloid beta-Peptides - metabolism; Animal models; Animals; ApoE; Apolipoproteins; Dementia; Dementia disorders; Disease Models, Animal; Genetic factors; Genomes; Gliosis; Health risk assessment; Heritability; Humans; Immune system; Life Sciences; Membrane Glycoproteins - genetics; Membrane Glycoproteins - metabolism; Microglia; Microglia - metabolism; Myeloid cells; Neurodegeneration; Neurofibrillary tangles; Neuropathology; Pathogenesis; Peptides; Plaque, Amyloid - pathology; Proteins; Receptors, Immunologic - genetics; Receptors, Immunologic - metabolism; Review; Senile plaques; Tau protein; TREM2; β-Amyloid; ApoE; TREM2; Gliosis; Alzheimer’s disease; Neurodegeneration; Microglia

Alzheimer's disease (AD) is the leading cause of dementia. The two histopathological markers of AD are amyloid plaques composed of the amyloid-β (Aβ) peptide, and neurofibrillary tangles of aggregated, abnormally hyperphosphorylated tau protein. The majority of AD cases are late-onset, after th...