Functional capacity of natural killer cells in HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients

• Published in: BMC infectious diseases Vol. 19; no. 1; pp. 433 - 9
• Main Authors: Queiroz, Gabriel Andrade Nonato, Mascarenhas, Rita Elizabeth Moreira, Vieillard, Vincent, Andrade, Raphaela Lisboa, Galvão-Castro, Bernardo, Grassi, Maria Fernanda Rios
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 17.05.2019; BioMed Central; BMC
• Subjects: Acquired immune deficiency syndrome; AIDS; Blood; Blood & organ donations; Cancer; CD107; Cell surface; Central nervous system diseases; Cytokines; Cytotoxicity; Degranulation; Dengue fever; Dermatitis; Diagnosis; Flow cytometry; Gene expression; Genetic aspects; Granzyme B; HAM/TSP; Hereditary spastic paraplegia; HIV; HTLV-1; HTLV-I infections; Human health and pathology; Human immunodeficiency virus; Immune system; Immunology; Infections; Infectious diseases; Innate immunity; Intelligence gathering; Killer cells; Leukemia; Life Sciences; Lymphocytes; Markers; Natural cytotoxicity receptor; Natural killer cells; NK cells; NKG2 antigen; NKp30; PD-1 protein; Perforin; Potassium channels (inwardly-rectifying); Receptors; Risk factors; Spasticity; Spinal cord; Toxicity; Toxicology; Tropical spastic paraparesis; Viral infections; Viruses; γ-Interferon; Brazil; United States > US; CD107; HAM/TSP; NK cells; HTLV-1; Natural cytotoxicity receptor; NKp30

Natural killer (NK) cells are part of the innate immune system and provide surveillance against viruses and cancers. The ability of NK cells to kill virus-infected cells depends on the balance between the effects of inhibitory and activating NK cell receptors. This study aimed to investigate the phe...