Network pharmacology and in vitro studies reveal the pharmacological effects and molecular mechanisms of Shenzhi Jiannao prescription against vascular dementia

• Published in: BMC complementary and alternative medicine Vol. 22; no. 1; p. 33
• Main Authors: Tian, Danfeng, Gao, Qiang, Chang, Ze, Lin, Jingfeng, Ma, Dayong, Han, Zhenyun
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 02.02.2022; BioMed Central; BMC
• Subjects: Acetylcholinesterase; Animals; Apoptosis; Binswanger's disease; Caspase-3; Cell death; Cell viability; Chemical composition; Chemical compounds; Chinese medicine; Cholinergics; Cognitive ability; Computer programs; Dementia; Dementia disorders; Dementia, Vascular - drug therapy; Dementia, Vascular - genetics; Drugs, Chinese Herbal - pharmacology; Drugs, Chinese Herbal - therapeutic use; Encyclopedias; Excitotoxicity; Genes; Genomes; Genomics; Glutamate; Herbal medicine; Imaging systems; In vitro methods and tests; In vitro studies; Kaempferol; Medical research; Medicine, Botanic; Medicine, Chinese Traditional; Medicine, Herbal; Molecular modelling; mRNA; Network Pharmacology; Neurotoxicity; Pharmaceuticals; Pharmacological effects and molecular mechanisms; Pharmacology; Pheochromocytoma cells; Phytosterols; Prescriptions; Protein interaction; Protein-protein interactions; Proteins; Rats; Regulatory mechanisms (biology); Shenzhi Jiannao prescription; Software; Therapeutic applications; Therapeutic targets; Traditional Chinese medicine; Variance analysis; Vascular dementia; China; United States > US; Asia; Japan; Pharmacological effects and molecular mechanisms; In vitro studies; Network pharmacology; Vascular dementia; Shenzhi Jiannao prescription

Shenzhi Jiannao (SZJN) prescription is a type of herbal formula adopted in the management of cognitive impairment and related disorders. However, its effects and related regulatory mechanisms on vascular dementia (VD) are elusive. Herein, network pharmacology prediction was employed to explore the p...