Integrated high-throughput analysis identifies super enhancers associated with chemoresistance in SCLC - Bao, Jiarong; Li, Man; Liang, Shumei; Yang, Yunchu; Wu, Jingfang; Zou, Qingqing; Fang, Shun; Chen, Size; Guo, Linlang (BMC medical genomics, 2019)
Keywords: Analysis; Bioinformatics; Biological response modifiers; Cancer; Cancer research; Cancer therapies; Care and treatment; Cell Line, Tumor; Chemoresistance; Chemotherapy; Chromatin; Computational Biology; CRISPR-Cas technology; Deoxyribonucleic acid; Disease; DNA; Drug resistance; Drug Resistance, Neoplasm - genetics; Enhancer Elements, Genetic - genetics; Enhancers; Forkhead protein; Foxp1 protein; Gene amplification; Gene expression; Gene regulation; Genetic aspects; Genomes; High-Throughput Nucleotide Sequencing; High-throughput screening (Biochemical assaying); Humans; Immunoprecipitation; Interferon; Interferon regulatory factor; Interferon regulatory factor 1; Leukemia; Lung cancer; Lung Neoplasms - genetics; Lung Neoplasms - pathology; Noncoding DNA; Polymerase chain reaction; Regulatory sequences; Reverse transcription; RNA; RNA interference; RNA polymerase; RNA sequencing; RNA-mediated interference; Sequence Analysis, RNA; Small cell lung cancer; Small cell lung carcinoma; Small Cell Lung Carcinoma - genetics; Small Cell Lung Carcinoma - pathology; Sp1 protein; Super enhancer; Therapeutic applications; Transcription (Genetics); Transcription factors; Transcription Factors - metabolism; Tumors; Small cell lung cancer; Chemoresistance; Super enhancer