DNA and RNA-sequence based GWAS highlights membrane-transport genes as key modulators of milk lactose content

• Published in: BMC genomics Vol. 18; no. 1; p. 968
• Main Authors: Lopdell, Thomas J, Tiplady, Kathryn, Struchalin, Maksim, Johnson, Thomas J J, Keehan, Michael, Sherlock, Ric, Couldrey, Christine, Davis, Stephen R, Snell, Russell G, Spelman, Richard J, Littlejohn, Mathew D
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 15.12.2017; BioMed Central; BMC
• Subjects: Alleles; Amino acid sequence; Animal lactation; Animals; Carbohydrates; Cattle; Channel gating; Dairy cattle; Dairy industry; Deoxyribonucleic acid; DNA; DNA sequencing; Endoplasmic reticulum; Female; Food; Food production; Fourier transforms; Gene Expression; Gene mapping; Genes; Genetic control; Genetic Variation; Genome sequencing; Genome-Wide Association Study; Genomes; Genomics; Genotype & phenotype; Genotypes; GWAS; Ion channels; Ion Transport - genetics; Lactation - genetics; Lactose; Lactose - metabolism; Membrane Transport Proteins - genetics; Membranes; Milk; Milk - metabolism; Modulators; Neonates; Nucleotide sequence; Peptide mapping; Phenotype; Phenotypes; Polymorphism, Single Nucleotide; Population; Potassium channels (inwardly-rectifying); Principal components analysis; Proteins; QTL mapping; Quantitative genetics; Quantitative Trait Loci; Ribonucleic acid; RNA; RNA sequencing; Sequence Analysis, DNA; Sequence Analysis, RNA; Transport; New Zealand; RNA sequencing; Lactose; GWAS; Genome sequencing; Milk; QTL mapping

Lactose provides an easily-digested energy source for neonates, and is the primary carbohydrate in milk in most species. Bovine lactose is also a key component of many human food products. However, compared to analyses of other milk components, the genetic control of lactose has been little studied....