5-Lipoxygenase Deficiency Reduces Acetaminophen-Induced Hepatotoxicity and Lethality

• Published in: BioMed research international Vol. 2013; no. 2013; pp. 1 - 13
• Main Authors: Cunha, Fernando Queiroz, Casagrande, Rúbia, Verri, Waldiceu A., Pinge-Filho, Phileno, da Silva, Rosiane V., Alves-Filho, José C., Cunha, Thiago Mattar, Crespigio, Jefferson, Pinho-Ribeiro, Felipe A., Cardoso, Renato D. R., Hohmann, Miriam S. N., Ferreira, Sergio Henrique
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2013; John Wiley & Sons, Inc; Hindawi Limited
• Subjects: Acetaminophen; Acetaminophen - adverse effects; Acetaminophen - pharmacology; Alanine Transaminase - blood; Alanine Transaminase - genetics; Analgesics, Non-Narcotic - adverse effects; Analgesics, Non-Narcotic - pharmacology; Analysis; Animals; Arachidonate 5-Lipoxygenase; Chemical and Drug Induced Liver Injury - enzymology; Chemical and Drug Induced Liver Injury - genetics; Chemical and Drug Induced Liver Injury - pathology; Cytokines - blood; Cytokines - genetics; Health aspects; Inflammation; Inflammation - chemically induced; Inflammation - enzymology; Inflammation - genetics; Inflammation - pathology; Ischemia; Membrane Glycoproteins - blood; Membrane Glycoproteins - genetics; Mice; Mice, Knockout; Mortality; NADPH Oxidase 2; NADPH Oxidases - blood; NADPH Oxidases - genetics; NF-E2-Related Factor 2 - blood; NF-E2-Related Factor 2 - genetics; Oxidation-Reduction - drug effects; Oxidative stress; Participation; Pathogenesis; Proteins; Risk factors; Rodents; Studies; Superoxides - blood

5-Lipoxygenase (5-LO) converts arachidonic acid into leukotrienes (LTs) and is involved in inflammation. At present, the participation of 5-LO in acetaminophen (APAP)-induced hepatotoxicity and liver damage has not been addressed. 5-LO deficient (5-LO-/-) mice and background wild type mice were chal...