Higher serum total cholesterol levels in late middle age are associated with glucose hypometabolism in brain regions affected by Alzheimer's disease and normal aging

• Published in: NeuroImage (Orlando, Fla.) Vol. 49; no. 1; pp. 169 - 176
• Main Authors: Reiman, Eric M., Chen, Kewei, Langbaum, Jessica B.S., Lee, Wendy, Reschke, Cole, Bandy, Daniel, Alexander, Gene E., Caselli, Richard J.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2010; Elsevier Limited
• Subjects: Age; Aged; Aging; Aging - metabolism; Alzheimer Disease - diagnostic imaging; Alzheimer Disease - genetics; Alzheimer Disease - metabolism; Alzheimer's disease; Anticholesteremic Agents - therapeutic use; Apolipoprotein E4 - genetics; Brain Chemistry - physiology; Brain Mapping; Cholesterol; Cholesterol - blood; Cognition & reasoning; Female; Glucose - metabolism; Health risk assessment; Heterozygote; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use; Hypercholesterolemia - blood; Lipid Metabolism - genetics; Lipid Metabolism - physiology; Lipids; Lipoproteins; Magnetic Resonance Imaging; Male; Memory; Middle Aged; Neuropathology; Neuropsychological Tests; Positron emission tomography; Risk; Studies; Aging; Alzheimer's disease; Positron emission tomography; Cholesterol

Epidemiological studies suggest that higher midlife serum total cholesterol levels are associated with an increased risk of Alzheimer's disease (AD). Using fluorodeoxyglucose positron emission tomography (PET) in the study of cognitively normal late middle-aged people, we demonstrated an associ...