肝硬化患者红细胞补体受体Ⅰ型分子密度相关基因多态性与其数量变化的研究

R575.2; 研究乙肝后肝硬化代偿和失代偿患者红细胞CR1分子数量及其与CR1密度相关基因多态性的关系,探讨肝炎后肝硬化红细胞膜分子的变化在肝硬化疾病发展中的意义.采用酶免疫分析间接法检测乙肝后肝硬化患者红细胞CR1分子数量;用PCR、HindⅢ酶切和凝胶电泳法检测红细胞CR1密度相关基因多态性.乙肝后肝硬化患者的红细胞CR1分子数量下降(P＜0.01),失代偿者尤为显著(P＜0.01).乙肝后肝硬化患者红细胞CR1分子数量下降与肝硬化发生、发展有关.红细胞CR1分子数量表达下降主要与后天性因素有关.对乙肝后肝硬化患者进行红细胞CR1分子测定或动态观察,对探讨肝炎后肝硬化的发病机理、预后和转...

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Published in临床肝胆病杂志 Vol. 19; no. 2; pp. 74 - 76
Main Authors 李阳, 王海滨, 黎雪如
Format Journal Article
LanguageChinese
Published 宁夏医学院微生物学和免疫学教研室,宁夏,银川,750004%解放军302医院临床检验中心,北京,100039 2003
Subjects
红细胞
补体受体Ⅰ型基因
乙肝后肝硬化
补体受体Ⅰ型
Online AccessGet full text
ISSN1001-5256
DOI10.3969/j.issn.1001-5256.2003.02.004

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Abstract R575.2; 研究乙肝后肝硬化代偿和失代偿患者红细胞CR1分子数量及其与CR1密度相关基因多态性的关系,探讨肝炎后肝硬化红细胞膜分子的变化在肝硬化疾病发展中的意义.采用酶免疫分析间接法检测乙肝后肝硬化患者红细胞CR1分子数量;用PCR、HindⅢ酶切和凝胶电泳法检测红细胞CR1密度相关基因多态性.乙肝后肝硬化患者的红细胞CR1分子数量下降(P＜0.01),失代偿者尤为显著(P＜0.01).乙肝后肝硬化患者红细胞CR1分子数量下降与肝硬化发生、发展有关.红细胞CR1分子数量表达下降主要与后天性因素有关.对乙肝后肝硬化患者进行红细胞CR1分子测定或动态观察,对探讨肝炎后肝硬化的发病机理、预后和转归具有重要意义.
AbstractList R575.2; 研究乙肝后肝硬化代偿和失代偿患者红细胞CR1分子数量及其与CR1密度相关基因多态性的关系,探讨肝炎后肝硬化红细胞膜分子的变化在肝硬化疾病发展中的意义.采用酶免疫分析间接法检测乙肝后肝硬化患者红细胞CR1分子数量;用PCR、HindⅢ酶切和凝胶电泳法检测红细胞CR1密度相关基因多态性.乙肝后肝硬化患者的红细胞CR1分子数量下降(P＜0.01),失代偿者尤为显著(P＜0.01).乙肝后肝硬化患者红细胞CR1分子数量下降与肝硬化发生、发展有关.红细胞CR1分子数量表达下降主要与后天性因素有关.对乙肝后肝硬化患者进行红细胞CR1分子测定或动态观察,对探讨肝炎后肝硬化的发病机理、预后和转归具有重要意义.
Author 黎雪如
李阳
王海滨
AuthorAffiliation 宁夏医学院微生物学和免疫学教研室,宁夏,银川,750004%解放军302医院临床检验中心,北京,100039
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Keywords 红细胞
补体受体Ⅰ型基因
乙肝后肝硬化
补体受体Ⅰ型
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Title 肝硬化患者红细胞补体受体Ⅰ型分子密度相关基因多态性与其数量变化的研究
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