DRD4 Rare Variants in Attention-Deficit/Hyperactivity Disorder (ADHD): Further Evidence from a Birth Cohort Study

• Published in: PloS one Vol. 8; no. 12; p. e85164
• Main Authors: Tovo-Rodrigues, Luciana, Rohde, Luis A., Menezes, Ana M. B., Polanczyk, Guilherme V., Kieling, Christian, Genro, Julia P., Anselmi, Luciana, Hutz, Mara H.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 31.12.2013; Public Library of Science (PLoS)
• Subjects: Adolescent; Alleles; Analysis; Attention Deficit Disorder with Hyperactivity - genetics; Attention Deficit Disorder with Hyperactivity - pathology; Attention deficit hyperactivity disorder; Base Sequence; Brazil; Child; Codons; Cohort analysis; Cohort Studies; Deoxyribonucleic acid; Disease susceptibility; DNA; Dopamine; Dopamine D4 receptors; Dopamine receptors; Genetic Association Studies; Genetic Predisposition to Disease - genetics; Genetic Variation; Haplotypes - genetics; Heterogeneity; Humans; Hyperactivity; Logistic Models; Medical research; Minisatellite Repeats - genetics; Molecular Sequence Data; Mutation; Odds Ratio; Receptors, Dopamine D4 - genetics; Sequence Analysis, DNA; Studies; Surveys and Questionnaires; Teenagers; Brazil; Rio Grande do Sul Brazil

The dopamine receptor D4 (DRD4) is one of the most studied candidate genes for Attention-Deficit/Hyperactivity Disorder (ADHD). An excess of rare variants and non-synonymous mutations in the VNTR region of 7R allele in ADHD subjects was observed in previous studies with clinical samples. We hypothes...