3D bioprinting of methacrylated hyaluronic acid (MeHA) hydrogel with intrinsic osteogenicity

• Published in: PloS one Vol. 12; no. 6; p. e0177628
• Main Authors: Poldervaart, Michelle T., Goversen, Birgit, de Ruijter, Mylene, Abbadessa, Anna, Melchels, Ferry P. W., Öner, F. Cumhur, Dhert, Wouter J. A., Vermonden, Tina, Alblas, Jacqueline
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 06.06.2017; Public Library of Science (PLoS)
• Subjects: 3D printing; Addition polymerization; Biocompatibility; Biodegradability; Biodegradation; Biology and life sciences; Biomedical materials; Bioprinting; Bone biomaterials; Bone marrow; Bone morphogenetic protein 2; Bone morphogenetic proteins; Bone Regeneration; Bones; Cell culture; Cell Differentiation - drug effects; Cell Survival - drug effects; Cells, Cultured - drug effects; Criteria; Crosslinking; Differentiation; Dynamic mechanical analysis; Elastic limit; Elastic properties; Engineering; Engineering and technology; Extracellular matrix; Gels; Glycosaminoglycans - chemical synthesis; Glycosaminoglycans - chemistry; Glycosaminoglycans - pharmacology; Humans; Hyaluronic acid; Hyaluronic Acid - chemical synthesis; Hyaluronic Acid - chemistry; Hyaluronic Acid - pharmacology; Hydrogel, Polyethylene Glycol Dimethacrylate - chemical synthesis; Hydrogel, Polyethylene Glycol Dimethacrylate - chemistry; Hydrogel, Polyethylene Glycol Dimethacrylate - pharmacology; Hydrogels; Irradiation; Light emitting diodes; Mechanical analysis; Mechanical properties; Mesenchymal Stromal Cells - drug effects; Mesenchyme; Mineralization; Modulus of elasticity; Molecular weight; NMR; Nuclear magnetic resonance; Osteogenesis - drug effects; Pharmaceutical sciences; Pharmaceuticals; Physical Sciences; Polymers; Polymethacrylic Acids - chemical synthesis; Polymethacrylic Acids - chemistry; Polymethacrylic Acids - pharmacology; Regenerative medicine; Research and Analysis Methods; Rheology; Rigidity; Skin care products; Stability; Stem cells; Stiffness; Stimuli; Storage; Stromal cells; Surgical implants; Tissue Engineering; Tissue Scaffolds; Ultraviolet radiation; Yield; Netherlands; Germany

In bone regenerative medicine there is a need for suitable bone substitutes. Hydrogels have excellent biocompatible and biodegradable characteristics, but their visco-elastic properties limit their applicability, especially with respect to 3D bioprinting. In this study, we modified the naturally occ...