Telomere length and outcome of treatment for pulmonary tuberculosis in a gold mining community

• Published in: Scientific reports Vol. 11; no. 1; pp. 4031 - 10
• Main Authors: Katoto, Patrick D. M. C., Kayembe-Kitenge, Tony, Pollitt, Krystal J. Godri, Martens, Dries S., Ghosh, Manosij, Nachega, Jean B., Nemery, Benoit, Nawrot, Tim S.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 17.02.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 692/1537; 692/53; 692/699; 692/699/255; 692/699/255/1856; Adolescent; Adult; Aged; Aging; Biomarkers, Pharmacological - blood; Child; Child, Preschool; Clinical outcomes; Democratic Republic of the Congo - epidemiology; DNA, Mitochondrial - analysis; DNA, Mitochondrial - drug effects; DNA, Mitochondrial - genetics; Female; Gold; HIV; Human immunodeficiency virus; Humanities and Social Sciences; Humans; Leukocytes; Male; Middle Aged; Miners; Mining; Mitochondrial DNA; multidisciplinary; Occupational Diseases - etiology; Oxidative stress; Peripheral blood; Proportional Hazards Models; Prospective Studies; Science; Science (multidisciplinary); Telomere - genetics; Telomere - metabolism; Telomere Homeostasis - drug effects; Telomere Homeostasis - genetics; Telomere Homeostasis - physiology; Telomeres; Tuberculosis; Tuberculosis, Pulmonary - genetics; Tuberculosis, Pulmonary - therapy; Democratic Republic of the Congo

Telomere length (TL) is a marker of ageing and mitochondrial DNA (mtDNA) is an early marker of inflammation caused by oxidative stress. We determined TL and mtDNA content among active pulmonary tuberculosis (PTB) patients to assess if these cellular biomarkers differed between artisanal miners and n...