Embedding Synthetic Microvascular Networks in Poly(Lactic Acid) Substrates with Rounded Cross-Sections for Cell Culture Applications

• Published in: PloS one Vol. 8; no. 9; p. e73188
• Main Authors: Huang, Jen-Huang, Kim, Jeongyun, Ding, Yufang, Jayaraman, Arul, Ugaz, Victor M.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 02.09.2013; Public Library of Science (PLoS)
• Subjects: Acids; Animals; Aorta - cytology; Biocompatibility; Biocompatible Materials - metabolism; Biomedical engineering; Biomimetics - methods; Biophysics; Blood Vessels - cytology; Cattle; Cell culture; Cell Culture Techniques - methods; Chemical engineering; Cross-sections; Embedding; Endothelial cells; Endothelial Cells - cytology; Endothelial Cells - metabolism; Hemodynamics; Lactic acid; Lactic Acid - metabolism; Lasers; Methods; Microtechnology - methods; Microvasculature; Mimicry; Networks; Physiological aspects; Polyesters; Polylactic acid; Polymers - metabolism; Substrates; Technology application; Time Factors; Tissue engineering; Topology; United States; United States > US; Texas

Synthetic microvascular networks are essential to enable in vitro studies of cell biology, biophysics, hemodynamics, and drug discovery, as well as in applications involving tissue engineering and artificial vasculature. But current limitations make it challenging to construct networks incorporating...