Detection of colorectal cancer (CRC) by urinary volatile organic compound analysis

• Published in: PloS one Vol. 9; no. 9; p. e108750
• Main Authors: Arasaradnam, Ramesh P, McFarlane, Michael J, Ryan-Fisher, Courtenay, Westenbrink, Erik, Hodges, Phoebe, Hodges, Paula, Thomas, Matthew G, Chambers, Samantha, O'Connell, Nicola, Bailey, Catherine, Harmston, Christopher, Nwokolo, Chuka U, Bardhan, Karna D, Covington, James A
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 30.09.2014; Public Library of Science (PLoS)
• Subjects: Adult; Aged; Analysis; Biomarkers; Biomarkers, Tumor - urine; Cancer; Cancer diagnosis; Chromatography; Cluster Analysis; Colorectal cancer; Colorectal carcinoma; Colorectal Neoplasms - diagnosis; Data processing; Discriminant Analysis; Disease; Engineering schools; Feature extraction; Female; Fermentation; Gas Chromatography-Mass Spectrometry; Gases; Gastroenterology; Gastrointestinal diseases; Headspace; Health aspects; Humans; Inflammatory bowel diseases; Intestine; Ion mobility spectroscopy; Ionic mobility; Male; Mass Spectrometry; Medical screening; Medicine and Health Sciences; Middle Aged; Mobility; Organic compounds; Patients; Pollution control; Prostate; Scientific imaging; Sensitivity; Sensitivity and Specificity; Spectroscopy; Tumors; Urine; VOCs; Volatile organic compounds; Volatile Organic Compounds - urine

Colorectal cancer (CRC) is a leading cause of cancer related death in Europe and the USA. There is no universally accepted effective non-invasive screening test for CRC. Guaiac based faecal occult blood (gFOB) testing has largely been superseded by Faecal Immunochemical testing (FIT), but sensitivit...