Co-repression of mismatch repair gene expression by hypoxia in cancer cells: Role of the Myc/Max network

• Published in: Cancer letters Vol. 252; no. 1; pp. 93 - 103
• Main Authors: Bindra, Ranjit S., Glazer, Peter M.
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 08.07.2007; Elsevier Limited
• Subjects: Adaptor Proteins, Signal Transducing - genetics; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism; Binding sites; c-Myc; Cell Cycle Proteins - metabolism; Cell Hypoxia; Cell Line, Tumor; Deoxyribonucleic acid; DNA; DNA Mismatch Repair; DNA repair; Down-Regulation; Gene amplification; Gene expression; Gene Expression Regulation, Neoplastic; Genetic instability; Genomic Instability - genetics; Hematology, Oncology and Palliative Medicine; Humans; Hypoxia; Hypoxia-Inducible Factor 1 - metabolism; Max network; MutL Protein Homolog 1; MutS Homolog 2 Protein - genetics; Neoplasms - genetics; Nuclear Proteins - genetics; Nuclear Proteins - metabolism; Promoter Regions, Genetic; Protein expression; Proteins; Proto-Oncogene Proteins c-myc - genetics; Proto-Oncogene Proteins c-myc - metabolism; Repressor Proteins - metabolism; Studies; Transcription factors; Hypoxia; Max network; Genetic instability; c-Myc; DNA mismatch repair

The key microenvironmental stress of hypoxia is associated with a diverse spectrum of alterations in both the expression and activation patterns of numerous DNA repair and stress-response factors. We have shown previously that hypoxia causes decreased expression of the mismatch repair gene, MLH1, le...