Multi-methodological approach for the Quality assessment of Senecionis scandentis Herba (Qianliguang) in the herbal market
We set forth to assess the quality of an herbal medicine sold in Hong Kong called Qianliguang by employing a multi-methodological approach. The quality is set by its identity, chemical composition, and bioactivities, among others. Qianliguang (Senecionis scandentis Herba, Senecio scandens Buch.-Ham....
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| Published in | PloS one Vol. 17; no. 4; p. e0267143 |
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| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
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Public Library of Science
14.04.2022
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| Abstract | We set forth to assess the quality of an herbal medicine sold in Hong Kong called Qianliguang by employing a multi-methodological approach. The quality is set by its identity, chemical composition, and bioactivities, among others. Qianliguang (Senecionis scandentis Herba, Senecio scandens Buch.-Ham. ex D.Don) has known antibacterial properties. However, it is poisonous and overconsumption can result in liver damage. Eighteen Qianliguang samples were purchased from herbal shops at various districts in Hong Kong. Samples were first authenticated organoleptically. DNA barcoding at the psbA-trnH , ITS2 , and rbcL loci was then conducted to confirm the species. HPLC-UV was performed to screen for the presence of the chemical compounds and to quantify the flavonoid hyperoside. UPLC-MS was used to quantify the amount of the toxic pyrrolizidine alkaloid (PA) adonifoline. Microdilution assay was performed to show the antibacterial effect on Streptococcus aureus and S . pneumoniae . Results showed that five samples were found to be substituted by species belonging to the genus Lespedeza ; four samples were mixtures containing not only Qianliguang but also Achyranthes aspera L., Lonicera confusa DC., or Solanum nigrum L. HPLC-UV showed that only ten contained enough hyperoside to meet the standard requirement. In addition, nine samples had adonifoline that exceeded the toxicity standard requirement. In the microdilution assay, samples containing Qianliguang showed inhibition on S . aureus and S . pneumoniae , while among the five Lespedeza sp. samples the antibacterial effects on S . aureus were not detectable; only one sample showed inhibition to S . pneumoniae . Our study illustrated the necessity of using a multi-methodological approach for herbal medicine quality assessment. We also showed that Qianliguang samples in the Hong Kong market were either toxic or adulterated. It is therefore essential to improve the quality control of Qianliguang and probably other herbs in the herbal market. |
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| AbstractList | We set forth to assess the quality of an herbal medicine sold in Hong Kong called Qianliguang by employing a multi-methodological approach. The quality is set by its identity, chemical composition, and bioactivities, among others. Qianliguang (Senecionis scandentis Herba, Senecio scandens Buch.-Ham. ex D.Don) has known antibacterial properties. However, it is poisonous and overconsumption can result in liver damage. Eighteen Qianliguang samples were purchased from herbal shops at various districts in Hong Kong. Samples were first authenticated organoleptically. DNA barcoding at the psbA-trnH, ITS2, and rbcL loci was then conducted to confirm the species. HPLC-UV was performed to screen for the presence of the chemical compounds and to quantify the flavonoid hyperoside. UPLC-MS was used to quantify the amount of the toxic pyrrolizidine alkaloid (PA) adonifoline. Microdilution assay was performed to show the antibacterial effect on Streptococcus aureus and S. pneumoniae. Results showed that five samples were found to be substituted by species belonging to the genus Lespedeza; four samples were mixtures containing not only Qianliguang but also Achyranthes aspera L., Lonicera confusa DC., or Solanum nigrum L. HPLC-UV showed that only ten contained enough hyperoside to meet the standard requirement. In addition, nine samples had adonifoline that exceeded the toxicity standard requirement. In the microdilution assay, samples containing Qianliguang showed inhibition on S. aureus and S. pneumoniae, while among the five Lespedeza sp. samples the antibacterial effects on S. aureus were not detectable; only one sample showed inhibition to S. pneumoniae. Our study illustrated the necessity of using a multi-methodological approach for herbal medicine quality assessment. We also showed that Qianliguang samples in the Hong Kong market were either toxic or adulterated. It is therefore essential to improve the quality control of Qianliguang and probably other herbs in the herbal market. We set forth to assess the quality of an herbal medicine sold in Hong Kong called Qianliguang by employing a multi-methodological approach. The quality is set by its identity, chemical composition, and bioactivities, among others. Qianliguang (Senecionis scandentis Herba, Senecio scandens Buch.-Ham. ex D.Don) has known antibacterial properties. However, it is poisonous and overconsumption can result in liver damage. Eighteen Qianliguang samples were purchased from herbal shops at various districts in Hong Kong. Samples were first authenticated organoleptically. DNA barcoding at the psbA-trnH, ITS2, and rbcL loci was then conducted to confirm the species. HPLC-UV was performed to screen for the presence of the chemical compounds and to quantify the flavonoid hyperoside. UPLC-MS was used to quantify the amount of the toxic pyrrolizidine alkaloid (PA) adonifoline. Microdilution assay was performed to show the antibacterial effect on Streptococcus aureus and S. pneumoniae. Results showed that five samples were found to be substituted by species belonging to the genus Lespedeza; four samples were mixtures containing not only Qianliguang but also Achyranthes aspera L., Lonicera confusa DC., or Solanum nigrum L. HPLC-UV showed that only ten contained enough hyperoside to meet the standard requirement. In addition, nine samples had adonifoline that exceeded the toxicity standard requirement. In the microdilution assay, samples containing Qianliguang showed inhibition on S. aureus and S. pneumoniae, while among the five Lespedeza sp. samples the antibacterial effects on S. aureus were not detectable; only one sample showed inhibition to S. pneumoniae. Our study illustrated the necessity of using a multi-methodological approach for herbal medicine quality assessment. We also showed that Qianliguang samples in the Hong Kong market were either toxic or adulterated. It is therefore essential to improve the quality control of Qianliguang and probably other herbs in the herbal market.We set forth to assess the quality of an herbal medicine sold in Hong Kong called Qianliguang by employing a multi-methodological approach. The quality is set by its identity, chemical composition, and bioactivities, among others. Qianliguang (Senecionis scandentis Herba, Senecio scandens Buch.-Ham. ex D.Don) has known antibacterial properties. However, it is poisonous and overconsumption can result in liver damage. Eighteen Qianliguang samples were purchased from herbal shops at various districts in Hong Kong. Samples were first authenticated organoleptically. DNA barcoding at the psbA-trnH, ITS2, and rbcL loci was then conducted to confirm the species. HPLC-UV was performed to screen for the presence of the chemical compounds and to quantify the flavonoid hyperoside. UPLC-MS was used to quantify the amount of the toxic pyrrolizidine alkaloid (PA) adonifoline. Microdilution assay was performed to show the antibacterial effect on Streptococcus aureus and S. pneumoniae. Results showed that five samples were found to be substituted by species belonging to the genus Lespedeza; four samples were mixtures containing not only Qianliguang but also Achyranthes aspera L., Lonicera confusa DC., or Solanum nigrum L. HPLC-UV showed that only ten contained enough hyperoside to meet the standard requirement. In addition, nine samples had adonifoline that exceeded the toxicity standard requirement. In the microdilution assay, samples containing Qianliguang showed inhibition on S. aureus and S. pneumoniae, while among the five Lespedeza sp. samples the antibacterial effects on S. aureus were not detectable; only one sample showed inhibition to S. pneumoniae. Our study illustrated the necessity of using a multi-methodological approach for herbal medicine quality assessment. We also showed that Qianliguang samples in the Hong Kong market were either toxic or adulterated. It is therefore essential to improve the quality control of Qianliguang and probably other herbs in the herbal market. We set forth to assess the quality of an herbal medicine sold in Hong Kong called Qianliguang by employing a multi-methodological approach. The quality is set by its identity, chemical composition, and bioactivities, among others. Qianliguang (Senecionis scandentis Herba, Senecio scandens Buch.-Ham. ex D.Don) has known antibacterial properties. However, it is poisonous and overconsumption can result in liver damage. Eighteen Qianliguang samples were purchased from herbal shops at various districts in Hong Kong. Samples were first authenticated organoleptically. DNA barcoding at the psbA-trnH , ITS2 , and rbcL loci was then conducted to confirm the species. HPLC-UV was performed to screen for the presence of the chemical compounds and to quantify the flavonoid hyperoside. UPLC-MS was used to quantify the amount of the toxic pyrrolizidine alkaloid (PA) adonifoline. Microdilution assay was performed to show the antibacterial effect on Streptococcus aureus and S . pneumoniae . Results showed that five samples were found to be substituted by species belonging to the genus Lespedeza ; four samples were mixtures containing not only Qianliguang but also Achyranthes aspera L., Lonicera confusa DC., or Solanum nigrum L. HPLC-UV showed that only ten contained enough hyperoside to meet the standard requirement. In addition, nine samples had adonifoline that exceeded the toxicity standard requirement. In the microdilution assay, samples containing Qianliguang showed inhibition on S . aureus and S . pneumoniae , while among the five Lespedeza sp. samples the antibacterial effects on S . aureus were not detectable; only one sample showed inhibition to S . pneumoniae . Our study illustrated the necessity of using a multi-methodological approach for herbal medicine quality assessment. We also showed that Qianliguang samples in the Hong Kong market were either toxic or adulterated. It is therefore essential to improve the quality control of Qianliguang and probably other herbs in the herbal market. |
| Audience | Academic |
| Author | Yu, Ho-Yin Harper, Rachel Ngai, Hiu-Lam Lau, David Tai-Wai Lee, Hung-Kay Chu, Adrian Jun Jacobsen, Alice B. J. E. Shaw, Pang-Chui Yang, Xiao |
| AuthorAffiliation | Institute for Biological Research, University of Belgrade, SERBIA 2 Department of Microbiology, The Chinese University of Hong Kong Kong, Hong Kong, China 3 Siu-Ying Hu Herbarium, School of Life Sciences, The Chinese University of Hong Kong, Hong Kong, China 1 School of Life Sciences, The Chinese University of Hong Kong, Hong Kong, China 4 Department of Chemistry, The Chinese University of Hong Kong, Hong Kong, China 5 LDS YYC R&D Centre for Chinese Medicine and Institute of Chinese Medicine, The Chinese University of Hong Kong, Hong Kong, China |
| AuthorAffiliation_xml | – name: 2 Department of Microbiology, The Chinese University of Hong Kong Kong, Hong Kong, China – name: 1 School of Life Sciences, The Chinese University of Hong Kong, Hong Kong, China – name: 4 Department of Chemistry, The Chinese University of Hong Kong, Hong Kong, China – name: 3 Siu-Ying Hu Herbarium, School of Life Sciences, The Chinese University of Hong Kong, Hong Kong, China – name: 5 LDS YYC R&D Centre for Chinese Medicine and Institute of Chinese Medicine, The Chinese University of Hong Kong, Hong Kong, China – name: Institute for Biological Research, University of Belgrade, SERBIA |
| Author_xml | – sequence: 1 givenname: Hiu-Lam surname: Ngai fullname: Ngai, Hiu-Lam – sequence: 2 givenname: Xiao surname: Yang fullname: Yang, Xiao – sequence: 3 givenname: Adrian Jun surname: Chu fullname: Chu, Adrian Jun – sequence: 4 givenname: Rachel surname: Harper fullname: Harper, Rachel – sequence: 5 givenname: Alice B. J. E. surname: Jacobsen fullname: Jacobsen, Alice B. J. E. – sequence: 6 givenname: David Tai-Wai orcidid: 0000-0002-3443-1808 surname: Lau fullname: Lau, David Tai-Wai – sequence: 7 givenname: Ho-Yin orcidid: 0000-0001-6258-2761 surname: Yu fullname: Yu, Ho-Yin – sequence: 8 givenname: Hung-Kay surname: Lee fullname: Lee, Hung-Kay – sequence: 9 givenname: Pang-Chui orcidid: 0000-0001-6848-5073 surname: Shaw fullname: Shaw, Pang-Chui |
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| CitedBy_id | crossref_primary_10_1016_j_aca_2024_342359 crossref_primary_10_1016_j_phyplu_2024_100727 crossref_primary_10_1016_j_heliyon_2023_e18946 |
| Cites_doi | 10.1007/s11306-011-0354-8 10.1371/journal.pone.0011533 10.1016/j.jpba.2011.05.004 10.1007/s13205-018-1169-3 10.1002/jms.4532 10.1016/j.jtcme.2021.07.005 10.1007/s00216-014-8175-z 10.15806/j.issn.2311-8571.2014.0010 10.1371/journal.pone.0257243 10.1002/tax.581003 10.1371/journal.pone.0217313 10.1016/j.jep.2013.05.048 10.1002/jemt.23651 |
| ContentType | Journal Article |
| Copyright | COPYRIGHT 2022 Public Library of Science 2022 Ngai et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2022 Ngai et al 2022 Ngai et al |
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| SubjectTerms | Anti-Bacterial Agents - pharmacology Antibacterial activity Biocompatibility Biology and Life Sciences Chemical composition Chemical compounds Chromatography, Liquid Computer and information sciences Deoxyribonucleic acid DNA DNA Barcoding, Taxonomic Evaluation Flavonoids Gene sequencing Genetic testing Herbal medicine High-performance liquid chromatography Lespedeza Life sciences Liquid chromatography Medicine Medicine and Health Sciences Medicine, Botanic Medicine, Herbal Methods Morphology Physical Sciences Plants, Medicinal - genetics Quality assessment Quality control Quality management Quality standards Research and analysis methods Senecio - genetics Staphylococcus aureus - genetics Tandem Mass Spectrometry Toxicity |
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| Title | Multi-methodological approach for the Quality assessment of Senecionis scandentis Herba (Qianliguang) in the herbal market |
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