Proinflammatory cytokines and lipopolysaccharides up regulate MMP-3 and MMP-13 production in Asian elephant (Elephas maximus) chondrocytes: attenuation by anti-arthritic agents

• Published in: BMC veterinary research Vol. 15; no. 1; p. 419
• Main Authors: Sirikaew, Nutnicha, Chomdej, Siriwadee, Tangyuenyong, Siriwan, Tangjitjaroen, Weerapongse, Somgird, Chaleamchat, Thitaram, Chatchote, Ongchai, Siriwan
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 21.11.2019; BioMed Central; BMC
• Subjects: active ingredients; andrographolide; animal diseases; Animals; Anti-Inflammatory Agents - pharmacology; Antiarthritic agents; Arthralgia; Arthritis; Asiatic elephant; captive animals; Captivity; cartilage; Cartilage diseases; Cells, Cultured; Chondrocytes; Chondrocytes - drug effects; Chondrocytes - metabolism; Collagenase 3; Cytokines; Cytokines - toxicity; Development and progression; Dexamethasone; Diseases; Drug dosages; Elephants - metabolism; Elephas maximus; Enzymes; Etoricoxib; Gene Expression Regulation, Enzymologic - drug effects; humans; IL-1β; Indomethacin; Inflammation; Interleukin 1; interleukin-17; interleukin-1beta; Interleukins; Kinases; lameness; Lipopolysaccharides; Lipopolysaccharides - toxicity; MAP kinase; Matrix metalloproteinase; Matrix Metalloproteinase 13 - genetics; Matrix Metalloproteinase 13 - metabolism; Matrix Metalloproteinase 3 - genetics; Matrix Metalloproteinase 3 - metabolism; medical treatment; Metalloproteinase; metalloproteinases; mitogen-activated protein kinase; Mitogens; MMP-13; MMP-3; Oncostatin M; Osteoarthritis; pain; Pathogenesis; Phosphorylation; Proinflammatory cytokines; Protein kinase; Proteins; Signal transduction; Stromelysin 1; Tumor necrosis factor; tumor necrosis factor-alpha; Tumor necrosis factor-TNF; Tumor necrosis factor-α; Up-Regulation - drug effects; United Kingdom; MMP-13; Proinflammatory cytokines; Osteoarthritis; Elephas maximus; MMP-3

Osteoarthritis (OA), the most common form of arthritic disease, results from destruction of joint cartilage and underlying bone. It affects animals, including Asian elephants (Elephas maximus) in captivity, leading to joint pain and lameness. However, publications regarding OA pathogenesis in this a...