Proinflammatory cytokines and lipopolysaccharides up regulate MMP-3 and MMP-13 production in Asian elephant (Elephas maximus) chondrocytes: attenuation by anti-arthritic agents - Sirikaew, Nutnicha; Chomdej, Siriwadee; Tangyuenyong, Siriwan; Tangjitjaroen, Weerapongse; Somgird, Chaleamchat; Thitaram, Chatchote; Ongchai, Siriwan (BMC veterinary research, 2019)
Keywords: active ingredients; andrographolide; animal diseases; Animals; Anti-Inflammatory Agents - pharmacology; Antiarthritic agents; Arthralgia; Arthritis; Asiatic elephant; captive animals; Captivity; cartilage; Cartilage diseases; Cells, Cultured; Chondrocytes; Chondrocytes - drug effects; Chondrocytes - metabolism; Collagenase 3; Cytokines; Cytokines - toxicity; Development and progression; Dexamethasone; Diseases; Drug dosages; Elephants - metabolism; Elephas maximus; Enzymes; Etoricoxib; Gene Expression Regulation, Enzymologic - drug effects; humans; IL-1β; Indomethacin; Inflammation; Interleukin 1; interleukin-17; interleukin-1beta; Interleukins; Kinases; lameness; Lipopolysaccharides; Lipopolysaccharides - toxicity; MAP kinase; Matrix metalloproteinase; Matrix Metalloproteinase 13 - genetics; Matrix Metalloproteinase 13 - metabolism; Matrix Metalloproteinase 3 - genetics; Matrix Metalloproteinase 3 - metabolism; medical treatment; Metalloproteinase; metalloproteinases; mitogen-activated protein kinase; Mitogens; MMP-13; MMP-3; Oncostatin M; Osteoarthritis; pain; Pathogenesis; Phosphorylation; Proinflammatory cytokines; Protein kinase; Proteins; Signal transduction; Stromelysin 1; Tumor necrosis factor; tumor necrosis factor-alpha; Tumor necrosis factor-TNF; Tumor necrosis factor-α; Up-Regulation - drug effects; United Kingdom; MMP-13; Proinflammatory cytokines; Osteoarthritis; Elephas maximus; MMP-3