Nanoparticle-releasing nanofiber composites for enhanced in vivo vaginal retention - Krogstad, Emily A.; Ramanathan, Renuka; Nhan, Christina; Kraft, John C.; Blakney, Anna K.; Cao, Shijie; Ho, Rodney J.Y.; Woodrow, Kim A. (Biomaterials, 2017)
Keywords: Administration, Intravaginal; animal models; Animals; composite materials; Delayed-Action Preparations - chemistry; drug delivery systems; Drug Delivery Systems - methods; drugs; Electrospinning; Female; fluorescence; Fluorescent Dyes - administration & dosage; Fluorescent Dyes - pharmacokinetics; Mice; Mice, Inbred C57BL; Microbicides; Mucous Membrane - metabolism; mucus; Nanofibers; Nanofibers - chemistry; Nanofibers - ultrastructure; Nanoparticles; Nanoparticles - administration & dosage; Nanoparticles - analysis; Nitriles; Pharmacokinetics; Pyridazines - administration & dosage; Pyridazines - pharmacokinetics; Pyrimidines; Reverse Transcriptase Inhibitors - administration & dosage; Reverse Transcriptase Inhibitors - pharmacokinetics; Vagina - metabolism; Vaginal drug delivery; vaginal mucosa; Nanoparticles; Electrospinning; Vaginal drug delivery; Microbicides; Nanofibers; Pharmacokinetics