The calcium chloride-induced rodent model of abdominal aortic aneurysm

• Published in: Atherosclerosis Vol. 226; no. 1; pp. 29 - 39
• Main Authors: Wang, Yutang, Krishna, Smriti, Golledge, Jonathan
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ireland Ltd 01.01.2013; Elsevier
• Subjects: Abdominal aortic aneurysm; administration & dosage; aneurysm; animal models; Animals; aorta; Aortic Aneurysm, Abdominal; Aortic Aneurysm, Abdominal - chemically induced; Aortic Aneurysm, Abdominal - metabolism; apoptosis; atherosclerosis; Atherosclerosis (general aspects, experimental research); Biological and medical sciences; biomarkers; Blood and lymphatic vessels; Calcification; calcium; Calcium chloride; Calcium Chloride - administration & dosage; Cardiology. Vascular system; Cardiovascular; chemically induced; chemokines; clinical trials; death; Disease Models, Animal; Diseases of the aorta; elastin; Extracellular matrix; genetically modified organisms; Humans; Inflammation; Matrix metalloproteinase; Medical sciences; men; metabolism; Mice; mitogen-activated protein kinase; oxidative stress; pathogenesis; patients; phospholipase A2; plasminogen; Rats; smooth muscle; Calcification; Extracellular matrix; Inflammation; Matrix metalloproteinase; Abdominal aortic aneurysm; Calcium chloride; Calcium; Rodentia; Cardiovascular disease; Inorganic element; Aortic aneurysm; Vascular disease; Vertebrata; Mammalia; Animal; Atherosclerosis

Abdominal aortic aneurysm (AAA) affects ∼5% men aged over 65 years and is an important cause of death in this population. Research into AAA pathogenesis has been fuelled by the need to identify new diagnostic biomarkers and therapeutic targets for this disease. One animal model of AAA involves peri-...