Associations of PFAS-related plasma metabolites with cholesterol and triglyceride concentrations

• Published in: Environmental research Vol. 216; no. Pt 2; p. 114570
• Main Authors: Schillemans, T., Bergdahl, I.A., Hanhineva, K., Shi, L., Donat-Vargas, C., Koponen, J., Kiviranta, H., Landberg, R., Åkesson, A., Brunius, C.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.01.2023
• Subjects: Adult; adults; Alkanesulfonic Acids; blood serum; Case-Control Studies; Cholesterol; Environmental Pollutants; Fluorocarbons; glycerophospholipids; HBM4EU; Humans; liquid chromatography; metabolism; metabolites; Metabolomics; Per- and polyfluoroalkyl substances; principal component analysis; Prospective Studies; triacylglycerols; Triglycerides; Metabolomics; HBM4EU; LC-PFAS; Triglycerides; Per- and polyfluoroalkyl substances; MCs; SC-PFAS; PFAS; Cholesterol; PPARs

The wide-spread environmental pollutants per- and polyfluoroalkyl substances (PFAS) have repeatedly been associated with elevated serum cholesterol in humans. However, underlying mechanisms are still unclear. Furthermore, we have previously observed inverse associations with plasma triglycerides. To...