Association of urinary ketamine and APOA1 levels with bladder dysfunction in ketamine abusers revealed via proteomics and targeted metabolite analyses

• Published in: Scientific reports Vol. 11; no. 1; pp. 9583 - 14
• Main Authors: Liu, Jo-Chuan, Chen, Yi-Ting, Hsieh, Ya-Ju, Wu, Chia-Chun, Huang, Ming-Chyi, Hsu, Yu-Chao, Wu, Chun-Te, Chen, Chih-Ken, Dash, Srinivas, Yu, Jau-Song
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 05.05.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 692/4025; 692/4025/1334; 692/699; 692/699/2768; Abuse; Bladder; Cystitis; Humanities and Social Sciences; Ketamine; Metabolites; Molecular modelling; multidisciplinary; Proteins; Proteomes; Proteomics; Science; Science (multidisciplinary)

Chronic ketamine abuse is associated with bladder dysfunction and cystitis. However, the effects of ketamine abuse on the urinary proteome profile and the correlations among urinary proteins, urinary ketamine (and metabolites) and clinicopathological features of ketamine-induced bladder dysfunction...