Associations of serum n-3 and n-6 polyunsaturated fatty acids with echocardiographic measures among older adults: the Hoorn Study
BACKGROUND/OBJECTIVES: Lower circulating polyunsaturated fatty acids (PUFAs) may induce loss of heart function. We investigated whether lower concentrations of n -3 and n -6 PUFAs were associated with less favourable echocardiographic measures and higher heart rate in older Caucasians, cross-section...
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Published in | European journal of clinical nutrition Vol. 67; no. 12; pp. 1277 - 1283 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
London
Nature Publishing Group UK
01.12.2013
Nature Publishing Group |
Subjects | |
Online Access | Get full text |
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Summary: | BACKGROUND/OBJECTIVES:
Lower circulating polyunsaturated fatty acids (PUFAs) may induce loss of heart function. We investigated whether lower concentrations of
n
-3 and
n
-6 PUFAs were associated with less favourable echocardiographic measures and higher heart rate in older Caucasians, cross-sectionally and after 7 years of follow-up.
SUBJECTS/METHODS:
We used data from the Hoorn Study, a population-based cohort. Cross-sectional data were available for 621 participants and longitudinal data for 336 participants. Mean age was 68.6±6.8 years at baseline. We performed linear regression analyses using
n
-3 and
n
-6 PUFAs quartiles—assayed by gas liquid chromatography—with left ventricular ejection fraction (LVEF), left ventricular mass index, left atrial volume index and heart rate.
RESULTS:
In multivariable analyses (regression coefficient (95% confidence interval)), the lowest eicosapentaenoic acid and docosahexaenoic acid quartiles compared with the highest quartiles were cross-sectionally associated with lower LVEF. Lower eicosapentaenoic acid and docosahexaenoic acid concentrations were associated with higher heart rate: 3.7 b.p.m. (1.5, 6.0;
P
for trend <0.001) and 3.4 b.p.m. (1.2, 5.6;
P
for trend 0.001), respectively. Multivariate longitudinal analyses showed a significant trend across quartiles for alpha-linolenic acid in relation to LVEF. The lowest linoleic acid quartile was significantly associated with a decreased LVEF of −4.0% compared with the highest quartile.
CONCLUSIONS:
This study found no strong evidence of longitudinal associations of eicosapentaenoic acid and docosahexaenoic acid with echocardiographic measures, however, lower concentrations of alpha-linolenic acid and linoleic acid were associated with decreased LVEF. These results provide evidence for a potential protective role of alpha-linolenic acid and linoleic acid in relation to systolic function. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0954-3007 1476-5640 |
DOI: | 10.1038/ejcn.2013.167 |