APP depletion alters selective pre- and post-synaptic proteins

• Published in: Molecular and cellular neuroscience Vol. 95; pp. 86 - 95
• Main Authors: Martinsson, Isak, Capetillo-Zarate, Estibaliz, Faideau, Mathilde, Willén, Katarina, Esteras, Noemi, Frykman, Susanne, Tjernberg, Lars O., Gouras, Gunnar K.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.03.2019
• Subjects: Alzheimer's disease; AMPA receptors; Amyloid; Amyloid precursor protein; Basic Medicine; Medical and Health Sciences; Medicin och hälsovetenskap; Medicinska och farmaceutiska grundvetenskaper; Neurosciences; Neurovetenskaper; Synapse; Synapse; Amyloid; AMPA receptors; Alzheimer's disease; Amyloid precursor protein

The normal role of Alzheimer's disease (AD)-linked amyloid precursor protein (APP) in the brain remains incompletely understood. Previous studies have reported that lack of APP has detrimental effects on spines and electrophysiological parameters. APP has been described to be important in synap...