Detection of glypican-1 (GPC-1) expression in urine cell sediments in prostate cancer

• Published in: PloS one Vol. 13; no. 4; p. e0196017
• Main Authors: Campbell, Douglas H, Lund, Maria E, Nocon, Aline L, Cozzi, Paul J, Frydenberg, Mark, De Souza, Paul, Schiller, Belinda, Beebe-Dimmer, Jennifer L, Ruterbusch, Julie J, Walsh, Bradley J
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 19.04.2018; Public Library of Science (PLoS)
• Subjects: Antigens; Assaying; Biological products; Biology and Life Sciences; Biomarkers; Biopsy; Bladder; Cancer; Cancer screening; Care and treatment; Cellular biology; Confidence intervals; Diagnosis; Earth Sciences; Glycoproteins; Health aspects; Heparan sulfate; Heparan sulfate proteoglycans; Hyperplasia; Immunofluorescence; Medical diagnosis; Medical research; Medicine; Medicine and Health Sciences; Monoclonal antibodies; Oncology; Patients; Prostate cancer; Prostatic hyperplasia; Research and Analysis Methods; Sediments; Sensitivity; Surveillance; Urine; Urology; Victoria Australia; Australia; Detroit Michigan; United States > US; New South Wales Australia; Michigan

While measurement of serum prostate specific antigen (PSA) is an important screening tool for prostate cancer, new biomarkers are necessary for better discrimination between presence and absence of disease. The MIL-38 monoclonal antibody is specific for the membrane glycoprotein glypican 1 (GPC-1) a...