The involvement and possible mechanism of pro-inflammatory tumor necrosis factor alpha (TNF-α) in thoracic ossification of the ligamentum flavum

• Published in: PloS one Vol. 12; no. 6; p. e0178986
• Main Authors: Zhang, Chi, Chen, Zhongqiang, Meng, Xiangyu, Li, Mengtao, Zhang, Li, Huang, Ann
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 02.06.2017; Public Library of Science (PLoS)
• Subjects: Activation; Analysis; Arthritis; Assaying; Biocompatibility; Biology and Life Sciences; Biomedical materials; Bone morphogenetic protein 2; c-Myc protein; Cell culture; Cell cycle; Cell Proliferation; Cells, Cultured; Central nervous system diseases; Cyclin D1; Cyclin D1 - immunology; Cytometry; Differentiation; Diseases; Enzyme inhibitors; Etiology; Extracellular signal-regulated kinase; Flow cytometry; Fractures; Gene expression; Genes; Genetic aspects; Hospitals; Humans; Inflammation; Inhibitors; JNK protein; Laboratories; Ligamentum Flavum - cytology; Ligamentum Flavum - immunology; Ligamentum Flavum - pathology; MAP kinase; MAP Kinase Signaling System; Medicine and Health Sciences; Metabolic pathways; Metabolism; Myc protein; Necrosis; Orthopedics; Ossification; Ossification (ectopic); Ossification, Heterotopic - immunology; Ossification, Heterotopic - pathology; Osteoblastogenesis; Osteoblasts - immunology; Osteoblasts - pathology; Osteogenesis; Pathogenesis; Patients; Physical Sciences; Polymerase chain reaction; Protein kinase; Proteins; Proteomics; Proto-Oncogene Proteins c-myc - immunology; Ribonucleic acid; RNA; S Phase; Spinal cord; Stimulation; Surgery; Thoracic Vertebrae - immunology; Thoracic Vertebrae - pathology; Thorax; Transcription; Transcription factors; Tumor necrosis factor; Tumor Necrosis Factor-alpha - immunology; Tumor necrosis factor-TNF; Beijing China; United States > US; China; Texas

Thoracic ossification of the ligamentum flavum (TOLF) is characterized by ectopic bone formation in the ligamentum flavum and is considered to be a leading cause of thoracic spinal canal stenosis and myelopathy. However, the underlying etiology is not well understood. An iTRAQ proteomics was used to...