NK cells negatively regulate CD8 T cells via natural cytotoxicity receptor (NCR) 1 during LCMV infection

• Published in: PLoS pathogens Vol. 15; no. 4; p. e1007725
• Main Authors: Pallmer, Katharina, Barnstorf, Isabel, Baumann, Nicolas S, Borsa, Mariana, Jonjic, Stipan, Oxenius, Annette
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.04.2019; Public Library of Science (PLoS)
• Subjects: Adaptive immunity; Antigen presentation; Antiviral agents; B cells; Biology and Life Sciences; CD8 antigen; Chronic infection; Computer architecture; Crosstalk; Cytokines; Cytomegalovirus; Cytotoxicity; Dendritic cells; Disruption; Health aspects; Immune response; Infection; Infections; Killer cells; Ligands; Lymphocytes; Lymphocytes T; Medicine and Health Sciences; Metastasis; Mice; Natural killer cells; Novels; Proteins; Research and Analysis Methods; Spleen; T cells; Toxicity; Viral infections; Viruses; Weight loss; Switzerland

Besides their function in recognizing cancerous and virally infected cells, natural killer (NK) cells have the potential to shape adaptive immune responses. However, the mechanisms employed by NK cells to negatively regulate virus-specific CD8 T cell responses remain to be fully defined. Using activ...