Enhanced proangiogenic potential of mesenchymal stem cell-derived exosomes stimulated by a nitric oxide releasing polymer

• Published in: Biomaterials Vol. 133; pp. 70 - 81
• Main Authors: Du, Wei, Zhang, Kaiyue, Zhang, Shuaiqiang, Wang, Ran, Nie, Yan, Tao, Hongyan, Han, Zhibo, Liang, Lu, Wang, Di, Liu, Jianfeng, Liu, Na, Han, Zhongchao, Kong, Deling, Zhao, Qiang, Li, Zongjin
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.07.2017
• Subjects: Advanced Basic Science; Angiogenesis; animal models; cell culture; Cells, Cultured; Dentistry; encapsulation; Exosome; exosomes; Exosomes - physiology; hindlimbs; human umbilical vein endothelial cells; Human Umbilical Vein Endothelial Cells - drug effects; Human Umbilical Vein Endothelial Cells - metabolism; Humans; ischemia; Mesenchymal stem cell(MSC); Mesenchymal Stromal Cells - drug effects; Mesenchymal Stromal Cells - metabolism; miR-126; Neovascularization, Physiologic - drug effects; Nitric oxide; Nitric Oxide - chemistry; Nitric Oxide - pharmacology; polymers; Polymers - chemistry; Signal Transduction - drug effects; stem cells; therapeutics; Vascular endothelial growth factor (VEGF); Vascular Endothelial Growth Factor A - metabolism; vascular endothelial growth factors; Angiogenesis; miR-126; Exosome; Nitric oxide; Vascular endothelial growth factor (VEGF); Mesenchymal stem cell(MSC)

Mesenchymal stem cell (MSC)-derived exosomes have been recognized as new candidates for the treatment of degenerative diseases or injury and may provide an alternative to cell-based therapy. However, the compositions in MSC-derived exosomes are highly influenced by the microenvironment in which thei...