Non-Alcoholic Fatty Liver Disease: The Emerging Burden in Cardiometabolic and Renal Diseases

As the number of individuals with non-alcoholic fatty liver disease (NAFLD) has increased, the influence of NAFLD on other metabolic diseases has been highlighted. Accumulating epidemiologic evidence indicates that NAFLD not only affects the liver but also increases the risk of extra-hepatic disease...

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Published inDiabetes & metabolism journal Vol. 41; no. 6; pp. 430 - 437
Main Authors Han, Eugene, Lee, Yong-ho
Format Journal Article
LanguageEnglish
Published Korea (South) Korean Diabetes Association / Daehan Dangnyobyeong Hakoe 01.12.2017
Korean Diabetes Association
대한당뇨병학회
Subjects
Arrhythmias, cardiac
Atherosclerosis
Blood pressure
Calcification
Cardiovascular disease
Coronary vessels
Diabetes
Diabetes mellitus
Drug dosages
High density lipoprotein
Hypertension
Inflammation
Insulin resistance
Kidney diseases
Lipids
Liver cancer
Liver cirrhosis
Liver diseases
Low density lipoprotein
Metabolic disorders
Metabolic syndrome
Metabolism
Mortality
Non-alcoholic fatty liver disease
Obesity
Regression analysis
Renal insufficiency
Review
Risk factors
Sarcopenia
Stroke
Veins & arteries
내과학
Hypertension
Obesity
Arrhythmias, cardiac
Renal insufficiency
Stroke
Diabetes mellitus
Atherosclerosis
Insulin resistance
Metabolism
Non-alcoholic fatty liver disease
Online AccessGet full text
ISSN2233-6079
2233-6087
DOI10.4093/dmj.2017.41.6.430

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Abstract As the number of individuals with non-alcoholic fatty liver disease (NAFLD) has increased, the influence of NAFLD on other metabolic diseases has been highlighted. Accumulating epidemiologic evidence indicates that NAFLD not only affects the liver but also increases the risk of extra-hepatic diseases such as type 2 diabetes mellitus, metabolic syndrome, dyslipidemia, hypertension, cardiovascular or cerebrovascular diseases, and chronic kidney disease. Non-alcoholic steatohepatitis, an advanced type of NAFLD, can aggravate these inter-organ relationships and lead to poorer outcomes. NAFLD induces insulin resistance and exacerbates systemic chronic inflammation and oxidative stress, which leads to organ dysfunction in extra-hepatic tissues. Although more research is needed to identify the pathophysiological mechanisms and causal relationship between NAFLD and cardiometabolic and renal diseases, screening for heart, brain, and kidney diseases, risk assessment for diabetes, and a multidisciplinary approach for managing these patients should be highly encouraged.
AbstractList As the number of individuals with non-alcoholic fatty liver disease (NAFLD) has increased, the influence of NAFLD on other metabolic diseases has been highlighted. Accumulating epidemiologic evidence indicates that NAFLD not only affects the liver but also increases the risk of extra-hepatic diseases such as type 2 diabetes mellitus, metabolic syndrome, dyslipidemia, hypertension, cardiovascular or cerebrovascular diseases, and chronic kidney disease. Non-alcoholic steatohepatitis, an advanced type of NAFLD, can aggravate these inter-organ relationships and lead to poorer outcomes. NAFLD induces insulin resistance and exacerbates systemic chronic inflammation and oxidative stress, which leads to organ dysfunction in extra-hepatic tissues. Although more research is needed to identify the pathophysiological mechanisms and causal relationship between NAFLD and cardiometabolic and renal diseases, screening for heart, brain, and kidney diseases, risk assessment for diabetes, and a multidisciplinary approach for managing these patients should be highly encouraged.
As the number of individuals with non-alcoholic fatty liver disease (NAFLD) has increased, the influence of NAFLD on other metabolic diseases has been highlighted. Accumulating epidemiologic evidence indicates that NAFLD not only affects the liver but also increases the risk of extra-hepatic diseases such as type 2 diabetes mellitus, metabolic syndrome, dyslipidemia, hypertension, cardiovascular or cerebrovascular diseases, and chronic kidney disease. Non-alcoholic steatohepatitis, an advanced type of NAFLD, can aggravate these inter-organ relationships and lead to poorer outcomes. NAFLD induces insulin resistance and exacerbates systemic chronic inflammation and oxidative stress, which leads to organ dysfunction in extra-hepatic tissues. Although more research is needed to identify the pathophysiological mechanisms and causal relationship between NAFLD and cardiometabolic and renal diseases, screening for heart, brain, and kidney diseases, risk assessment for diabetes, and a multidisciplinary approach for managing these patients should be highly encouraged.As the number of individuals with non-alcoholic fatty liver disease (NAFLD) has increased, the influence of NAFLD on other metabolic diseases has been highlighted. Accumulating epidemiologic evidence indicates that NAFLD not only affects the liver but also increases the risk of extra-hepatic diseases such as type 2 diabetes mellitus, metabolic syndrome, dyslipidemia, hypertension, cardiovascular or cerebrovascular diseases, and chronic kidney disease. Non-alcoholic steatohepatitis, an advanced type of NAFLD, can aggravate these inter-organ relationships and lead to poorer outcomes. NAFLD induces insulin resistance and exacerbates systemic chronic inflammation and oxidative stress, which leads to organ dysfunction in extra-hepatic tissues. Although more research is needed to identify the pathophysiological mechanisms and causal relationship between NAFLD and cardiometabolic and renal diseases, screening for heart, brain, and kidney diseases, risk assessment for diabetes, and a multidisciplinary approach for managing these patients should be highly encouraged.
As the number of individuals with non-alcoholic fatty liver disease (NAFLD) has increased, the influence of NAFLD on other metabolic diseases has been highlighted. Accumulating epidemiologic evidence indicates that NAFLD not only affects the liver but also increases the risk of extra-hepatic diseases such as type 2 diabetes mellitus, metabolic syndrome, dyslipidemia, hypertension, cardiovascular or cerebrovascular diseases, and chronic kidney disease. Non-alcoholic steatohepatitis, an advanced type of NAFLD, can aggravate these inter-organ relationships and lead to poorer outcomes. NAFLD induces insulin resistance and exacerbates systemic chronic inflammation and oxidative stress, which leads to organ dysfunction in extra-hepatic tissues. Although more research is needed to identify the pathophysiological mechanisms and causal relationship between NAFLD and cardiometabolic and renal diseases, screening for heart, brain, and kidney diseases, risk assessment for diabetes, and a multidisciplinary approach for managing these patients should be highly encouraged. KCI Citation Count: 47
Author Lee, Yong-ho
Han, Eugene
AuthorAffiliation 1 Division of Endocrinology and Metabolism, Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea
2 Graduate School, Yonsei University College of Medicine, Seoul, Korea
3 Division of Endocrinology and Metabolism, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
AuthorAffiliation_xml – name: 2 Graduate School, Yonsei University College of Medicine, Seoul, Korea
– name: 1 Division of Endocrinology and Metabolism, Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea
– name: 3 Division of Endocrinology and Metabolism, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
Author_xml – sequence: 1
  givenname: Eugene
  surname: Han
  fullname: Han, Eugene
  organization: Division of Endocrinology and Metabolism, Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea., Graduate School, Yonsei University College of Medicine, Seoul, Korea
– sequence: 2
  givenname: Yong-ho
  orcidid: 0000-0002-6219-4942
  surname: Lee
  fullname: Lee, Yong-ho
  organization: Graduate School, Yonsei University College of Medicine, Seoul, Korea., Division of Endocrinology and Metabolism, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
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Issue 6
Keywords Hypertension
Obesity
Arrhythmias, cardiac
Renal insufficiency
Stroke
Diabetes mellitus
Atherosclerosis
Insulin resistance
Metabolism
Non-alcoholic fatty liver disease
Language English
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– reference: 16012941 - Gastroenterology. 2005 Jul;129(1):113-21
– reference: 20620743 - J Am Coll Cardiol. 2010 Jul 13;56(3):225-33
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Snippet As the number of individuals with non-alcoholic fatty liver disease (NAFLD) has increased, the influence of NAFLD on other metabolic diseases has been...
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StartPage 430
SubjectTerms Arrhythmias, cardiac
Atherosclerosis
Blood pressure
Calcification
Cardiovascular disease
Coronary vessels
Diabetes
Diabetes mellitus
Drug dosages
High density lipoprotein
Hypertension
Inflammation
Insulin resistance
Kidney diseases
Lipids
Liver cancer
Liver cirrhosis
Liver diseases
Low density lipoprotein
Metabolic disorders
Metabolic syndrome
Metabolism
Mortality
Non-alcoholic fatty liver disease
Obesity
Regression analysis
Renal insufficiency
Review
Risk factors
Sarcopenia
Stroke
Veins & arteries
내과학
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Title Non-Alcoholic Fatty Liver Disease: The Emerging Burden in Cardiometabolic and Renal Diseases
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Volume 41
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