Continuous ASL perfusion fMRI investigation of higher cognition: Quantification of tonic CBF changes during sustained attention and working memory tasks

• Published in: NeuroImage (Orlando, Fla.) Vol. 31; no. 1; pp. 376 - 385
• Main Authors: Kim, Junghoon, Whyte, John, Wang, Jiongjiong, Rao, Hengyi, Tang, Kathy Z., Detre, John A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.05.2006; Elsevier Limited
• Subjects: 2-back task; Adult; Arterial spin labeling; Attention - physiology; Attention deficit hyperactivity disorder; Brain; Brain - blood supply; Brain - physiology; Brain Mapping; CASL; Cerebral blood flow; Cerebral Cortex - blood supply; Cerebral Cortex - physiology; Clinical neuroimaging; Cognition - physiology; Dominance, Cerebral - physiology; Feasibility Studies; Female; Frontal Lobe - blood supply; Frontal Lobe - physiology; Gyrus Cinguli - blood supply; Gyrus Cinguli - physiology; Humans; Image Processing, Computer-Assisted - methods; Magnetic Resonance Imaging - methods; Male; Medical imaging; Memory, Short-Term - physiology; Middle Aged; Nerve Net - physiology; Occipital Lobe - blood supply; Occipital Lobe - physiology; Oxygen - blood; Parietal Lobe - blood supply; Parietal Lobe - physiology; Pattern Recognition, Visual - physiology; Psychomotor Performance - physiology; Reaction Time - physiology; Regional Blood Flow - physiology; Studies; CASL; Clinical neuroimaging; 2-back task; Cerebral blood flow; Arterial spin labeling

Arterial spin labeling (ASL) perfusion fMRI is an emerging method in clinical neuroimaging. Its non-invasiveness, absence of low frequency noise, and ability to quantify the absolute level of cerebral blood flow (CBF) make the method ideal for longitudinal designs or low frequency paradigms. Despite...