Clustered DNA double-strand break formation and the repair pathway following heavy-ion irradiation

• Published in: Journal of radiation research Vol. 60; no. 1; pp. 69 - 79
• Main Authors: Hagiwara, Yoshihiko, Oike, Takahiro, Niimi, Atsuko, Yamauchi, Motohiro, Sato, Hiro, Limsirichaikul, Siripan, Held, Kathryn D, Nakano, Takashi, Shibata, Atsushi
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.01.2019
• Subjects: Aberration; Cancer; Chromosome abnormalities; Density; DNA; DNA damage; Energy transfer; Energy transformation; Gamma irradiation; Gamma rays; Genetic aspects; Heavy ions; Ion irradiation; Ionizing radiation; Lesions; Linear energy transfer (LET); Microscopy; Observations; Particle tracking; Radiation damage; Radiation exposure; Radiotherapy; Review; X ray irradiation; Japan; radiotherapy; cancer treatment; heavy-ion irradiation; DNA double-strand breaks; super-resolution microscopy; DSB repair pathway

Abstract Photons, such as X- or γ-rays, induce DNA damage (distributed throughout the nucleus) as a result of low-density energy deposition. In contrast, particle irradiation with high linear energy transfer (LET) deposits high-density energy along the particle track. High-LET heavy-ion irradiation...