A star-shaped porphyrin-arginine functionalized poly(l-lysine) copolymer for photo-enhanced drug and gene co-delivery

The co-delivery of drug and gene has become the primary strategy in cancer and other disease therapy. To co-deliver hydrophobic drug and functional gene efficiently into tumor cells, a star-shaped copolymer (PP-PLLD-Arg) with a photochemical internalization effect consisting of a porphyrin (PP) core...

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Published inBiomaterials Vol. 35; no. 14; pp. 4357 - 4367
Main Authors Ma, Dong, Lin, Qian-Ming, Zhang, Li-Ming, Liang, Yuan-Yuan, Xue, Wei
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Ltd 01.05.2014
Subjects
Advanced Basic Science
Animals
apoptosis
Apoptosis - drug effects
Arginine
Arginine - chemistry
biocompatibility
Biocompatible Materials - pharmacology
Cell Line, Tumor
Chromatography, Gel
Co-delivery
composite polymers
cytotoxicity
Dentistry
Drug Delivery Systems
drugs
Female
Flow Cytometry
Gene Transfer Techniques
genes
hemolysis
Hemolysis - drug effects
Humans
hydrophobicity
irradiation
Light
Lysine
Magnetic Resonance Spectroscopy
Matrix Metalloproteinase 9 - genetics
Matrix Metalloproteinase 9 - metabolism
Mice
neoplasm cells
neoplasms
Particle Size
Photo-enhanced
photochemistry
plasmids
Polylysine - chemical synthesis
Polylysine - chemistry
Porphyrin
porphyrins
Porphyrins - chemical synthesis
Porphyrins - chemistry
Protein Binding - drug effects
protein synthesis
RNA, Messenger - genetics
RNA, Messenger - metabolism
Star polymers
Static Electricity
Taxoids - pharmacology
therapeutics
Transfection
Star polymers
Co-delivery
Arginine
Lysine
Porphyrin
Photo-enhanced
Online AccessGet full text

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Abstract The co-delivery of drug and gene has become the primary strategy in cancer and other disease therapy. To co-deliver hydrophobic drug and functional gene efficiently into tumor cells, a star-shaped copolymer (PP-PLLD-Arg) with a photochemical internalization effect consisting of a porphyrin (PP) core and arginine-functionalized poly(l-lysine) dendron (PLLD-Arg) arms has been designed, and used to co-deliver docetaxel (DOC) and MMP-9 shRNA plasmid for nasopharyngeal cancer therapy. It was found that PP-PLLD-Arg/MMP-9 nanocomplex showed the photo-enhanced gene transfection efficiency in vitro, and could mediate a significant reduce of MMP-9 protein expression in HNE-1 cells. For co-delivery analysis, the obtained PP-PLLD-Arg/DOC/MMP-9 complexes could induce a more significant apoptosis than DOC or MMP-9 used only, and decreased invasive capacity of HNE-1 cells. Moreover, the star-shaped copolymer exhibited better blood compatibility and lower cytotoxicity compared to PEI-25k in the hemolysis and MTT assays, and also showed a good biocompatibility in vivo. Therefore, PP-PLLD-Arg with suited irradiation is a promising non-toxic and photo-inducible effective drug and gene delivery strategy, which should be encouraged in tumor therapy.
AbstractList The co-delivery of drug and gene has become the primary strategy in cancer and other disease therapy. To co-deliver hydrophobic drug and functional gene efficiently into tumor cells, a star-shaped copolymer (PP-PLLD-Arg) with a photochemical internalization effect consisting of a porphyrin (PP) core and arginine-functionalized poly(l-lysine) dendron (PLLD-Arg) arms has been designed, and used to co-deliver docetaxel (DOC) and MMP-9 shRNA plasmid for nasopharyngeal cancer therapy. It was found that PP-PLLD-Arg/MMP-9 nanocomplex showed the photo-enhanced gene transfection efficiency in vitro, and could mediate a significant reduce of MMP-9 protein expression in HNE-1 cells. For co-delivery analysis, the obtained PP-PLLD-Arg/DOC/MMP-9 complexes could induce a more significant apoptosis than DOC or MMP-9 used only, and decreased invasive capacity of HNE-1 cells. Moreover, the star-shaped copolymer exhibited better blood compatibility and lower cytotoxicity compared to PEI-25k in the hemolysis and MTT assays, and also showed a good biocompatibility in vivo. Therefore, PP-PLLD-Arg with suited irradiation is a promising non-toxic and photo-inducible effective drug and gene delivery strategy, which should be encouraged in tumor therapy.
Abstract The co-delivery of drug and gene has become the primary strategy in cancer and other disease therapy. To co-deliver hydrophobic drug and functional gene efficiently into tumor cells, a star-shaped copolymer (PP-PLLD-Arg) with a photochemical internalization effect consisting of a porphyrin (PP) core and arginine-functionalized poly( l -lysine) dendron (PLLD-Arg) arms has been designed, and used to co-deliver docetaxel (DOC) and MMP-9 shRNA plasmid for nasopharyngeal cancer therapy. It was found that PP-PLLD-Arg/MMP-9 nanocomplex showed the photo-enhanced gene transfection efficiency in vitro , and could mediate a significant reduce of MMP-9 protein expression in HNE-1 cells. For co-delivery analysis, the obtained PP-PLLD-Arg/DOC/MMP-9 complexes could induce a more significant apoptosis than DOC or MMP-9 used only, and decreased invasive capacity of HNE-1 cells. Moreover, the star-shaped copolymer exhibited better blood compatibility and lower cytotoxicity compared to PEI-25k in the hemolysis and MTT assays, and also showed a good biocompatibility in vivo . Therefore, PP-PLLD-Arg with suited irradiation is a promising non-toxic and photo-inducible effective drug and gene delivery strategy, which should be encouraged in tumor therapy.
The co-delivery of drug and gene has become the primary strategy in cancer and other disease therapy. To co-deliver hydrophobic drug and functional gene efficiently into tumor cells, a star-shaped copolymer (PP-PLLD-Arg) with a photochemical internalization effect consisting of a porphyrin (PP) core and arginine-functionalized poly(l-lysine) dendron (PLLD-Arg) arms has been designed, and used to co-deliver docetaxel (DOC) and MMP-9 shRNA plasmid for nasopharyngeal cancer therapy. It was found that PP-PLLD-Arg/MMP-9 nanocomplex showed the photo-enhanced gene transfection efficiency in vitro, and could mediate a significant reduce of MMP-9 protein expression in HNE-1 cells. For co-delivery analysis, the obtained PP-PLLD-Arg/DOC/MMP-9 complexes could induce a more significant apoptosis than DOC or MMP-9 used only, and decreased invasive capacity of HNE-1 cells. Moreover, the star-shaped copolymer exhibited better blood compatibility and lower cytotoxicity compared to PEI-25k in the hemolysis and MTT assays, and also showed a good biocompatibility in vivo. Therefore, PP-PLLD-Arg with suited irradiation is a promising non-toxic and photo-inducible effective drug and gene delivery strategy, which should be encouraged in tumor therapy.
The co-delivery of drug and gene has become the primary strategy in cancer and other disease therapy. To co-deliver hydrophobic drug and functional gene efficiently into tumor cells, a star-shaped copolymer (PP-PLLD-Arg) with a photochemical internalization effect consisting of a porphyrin (PP) core and arginine-functionalized poly(L-lysine) dendron (PLLD-Arg) arms has been designed, and used to co-deliver docetaxel (DOC) and MMP-9 shRNA plasmid for nasopharyngeal cancer therapy. It was found that PP-PLLD-Arg/MMP-9 nanocomplex showed the photo-enhanced gene transfection efficiency in vitro, and could mediate a significant reduce of MMP-9 protein expression in HNE-1 cells. For co-delivery analysis, the obtained PP-PLLD-Arg/DOC/MMP-9 complexes could induce a more significant apoptosis than DOC or MMP-9 used only, and decreased invasive capacity of HNE-1 cells. Moreover, the star-shaped copolymer exhibited better blood compatibility and lower cytotoxicity compared to PEI-25k in the hemolysis and MTT assays, and also showed a good biocompatibility in vivo. Therefore, PP-PLLD-Arg with suited irradiation is a promising non-toxic and photo-inducible effective drug and gene delivery strategy, which should be encouraged in tumor therapy.The co-delivery of drug and gene has become the primary strategy in cancer and other disease therapy. To co-deliver hydrophobic drug and functional gene efficiently into tumor cells, a star-shaped copolymer (PP-PLLD-Arg) with a photochemical internalization effect consisting of a porphyrin (PP) core and arginine-functionalized poly(L-lysine) dendron (PLLD-Arg) arms has been designed, and used to co-deliver docetaxel (DOC) and MMP-9 shRNA plasmid for nasopharyngeal cancer therapy. It was found that PP-PLLD-Arg/MMP-9 nanocomplex showed the photo-enhanced gene transfection efficiency in vitro, and could mediate a significant reduce of MMP-9 protein expression in HNE-1 cells. For co-delivery analysis, the obtained PP-PLLD-Arg/DOC/MMP-9 complexes could induce a more significant apoptosis than DOC or MMP-9 used only, and decreased invasive capacity of HNE-1 cells. Moreover, the star-shaped copolymer exhibited better blood compatibility and lower cytotoxicity compared to PEI-25k in the hemolysis and MTT assays, and also showed a good biocompatibility in vivo. Therefore, PP-PLLD-Arg with suited irradiation is a promising non-toxic and photo-inducible effective drug and gene delivery strategy, which should be encouraged in tumor therapy.
Author Lin, Qian-Ming
Xue, Wei
Ma, Dong
Zhang, Li-Ming
Liang, Yuan-Yuan
Author_xml – sequence: 1
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  surname: Ma
  fullname: Ma, Dong
  organization: Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, Jinan University, Guangzhou 510632, China
– sequence: 2
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  surname: Lin
  fullname: Lin, Qian-Ming
  organization: Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, Jinan University, Guangzhou 510632, China
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  givenname: Li-Ming
  surname: Zhang
  fullname: Zhang, Li-Ming
  email: ceszhlm@mail.sysu.edu.cn
  organization: Institute of Polymer Science, School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China
– sequence: 4
  givenname: Yuan-Yuan
  surname: Liang
  fullname: Liang, Yuan-Yuan
  organization: Research Center for Biomedicine and Health, Hangzhou Normal University, Hangzhou 310012, China
– sequence: 5
  givenname: Wei
  surname: Xue
  fullname: Xue, Wei
  email: weixue_jnu@aliyun.com.cn, gdmljt@gmail.com
  organization: Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, Jinan University, Guangzhou 510632, China
BackLink https://www.ncbi.nlm.nih.gov/pubmed/24576804$$D View this record in MEDLINE/PubMed
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Copyright 2014 Elsevier Ltd
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Issue 14
Keywords Star polymers
Co-delivery
Arginine
Lysine
Porphyrin
Photo-enhanced
Language English
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Snippet The co-delivery of drug and gene has become the primary strategy in cancer and other disease therapy. To co-deliver hydrophobic drug and functional gene...
Abstract The co-delivery of drug and gene has become the primary strategy in cancer and other disease therapy. To co-deliver hydrophobic drug and functional...
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StartPage 4357
SubjectTerms Advanced Basic Science
Animals
apoptosis
Apoptosis - drug effects
Arginine
Arginine - chemistry
biocompatibility
Biocompatible Materials - pharmacology
Cell Line, Tumor
Chromatography, Gel
Co-delivery
composite polymers
cytotoxicity
Dentistry
Drug Delivery Systems
drugs
Female
Flow Cytometry
Gene Transfer Techniques
genes
hemolysis
Hemolysis - drug effects
Humans
hydrophobicity
irradiation
Light
Lysine
Magnetic Resonance Spectroscopy
Matrix Metalloproteinase 9 - genetics
Matrix Metalloproteinase 9 - metabolism
Mice
neoplasm cells
neoplasms
Particle Size
Photo-enhanced
photochemistry
plasmids
Polylysine - chemical synthesis
Polylysine - chemistry
Porphyrin
porphyrins
Porphyrins - chemical synthesis
Porphyrins - chemistry
Protein Binding - drug effects
protein synthesis
RNA, Messenger - genetics
RNA, Messenger - metabolism
Star polymers
Static Electricity
Taxoids - pharmacology
therapeutics
Transfection
Title A star-shaped porphyrin-arginine functionalized poly(l-lysine) copolymer for photo-enhanced drug and gene co-delivery
URI https://www.clinicalkey.com/#!/content/1-s2.0-S0142961214001008
https://www.clinicalkey.es/playcontent/1-s2.0-S0142961214001008
https://dx.doi.org/10.1016/j.biomaterials.2014.01.070
https://www.ncbi.nlm.nih.gov/pubmed/24576804
https://www.proquest.com/docview/1506415504
https://www.proquest.com/docview/2101315385
Volume 35
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