Sphingosine-1-phosphate receptors control B-cell migration through signaling components associated with primary immunodeficiencies, chronic lymphocytic leukemia, and multiple sclerosis - Sic, Heiko; Kraus, Helene; Madl, Josef; Flittner, Karl-Andreas; von Münchow, Audrey Lilly; Pieper, Kathrin; Rizzi, Marta; Kienzler, Anne-Kathrin; Ayata, Korcan; Rauer, Sebastian; Kleuser, Burkhard; Salzer, Ulrich; et al. (Journal of allergy and clinical immunology, 2014)
Keywords: Adaptor Proteins, Signal Transducing - genetics; Adaptor Proteins, Signal Transducing - immunology; Adaptor Proteins, Signal Transducing - metabolism; Allergy and Immunology; Antigens, CD - genetics; Antigens, CD - immunology; Antigens, CD - metabolism; Antigens, Differentiation, T-Lymphocyte - genetics; Antigens, Differentiation, T-Lymphocyte - immunology; Antigens, Differentiation, T-Lymphocyte - metabolism; Arrestins - genetics; Arrestins - immunology; Arrestins - metabolism; autoimmunity; B cells; B-Lymphocyte Subsets - immunology; B-Lymphocyte Subsets - metabolism; B-Lymphocyte Subsets - pathology; beta-Arrestin 2; beta-Arrestins; Cell Line; Cell Movement; circulation; Common Variable Immunodeficiency - genetics; Common Variable Immunodeficiency - immunology; Common Variable Immunodeficiency - metabolism; Common Variable Immunodeficiency - pathology; fingolimod; FTY720; Gene Expression Regulation; Guanine Nucleotide Exchange Factors - genetics; Guanine Nucleotide Exchange Factors - immunology; Guanine Nucleotide Exchange Factors - metabolism; Humans; Immune system; Immunoglobulins; Lectins, C-Type - genetics; Lectins, C-Type - immunology; Lectins, C-Type - metabolism; Leukemia, Lymphocytic, Chronic, B-Cell - genetics; Leukemia, Lymphocytic, Chronic, B-Cell - immunology; Leukemia, Lymphocytic, Chronic, B-Cell - metabolism; Leukemia, Lymphocytic, Chronic, B-Cell - pathology; Lymphocyte receptors; Lymphocytes; migration; Multiple Sclerosis - genetics; Multiple Sclerosis - immunology; Multiple Sclerosis - metabolism; Multiple Sclerosis - pathology; Mutation; Primary Cell Culture; primary immunodeficiencies; Protein Isoforms - genetics; Protein Isoforms - immunology; Protein Isoforms - metabolism; Protein-Tyrosine Kinases - genetics; Protein-Tyrosine Kinases - immunology; Protein-Tyrosine Kinases - metabolism; Receptors, Lysosphingolipid - genetics; Receptors, Lysosphingolipid - immunology; Receptors, Lysosphingolipid - metabolism; Signal Transduction; Sphingosine-1-phosphate; Time-Lapse Imaging; Wiskott-Aldrich Syndrome Protein - genetics; Wiskott-Aldrich Syndrome Protein - immunology; Wiskott-Aldrich Syndrome Protein - metabolism; ALL; ROCK; DMSO; DOCK8; TIRFM; WAS; BFP; B-CLL; GFP; FITC; cALL; S1P; fingolimod; Sphingosine-1-phosphate; qPCR; TLR; GC; RFP; LRBA; MS; MACS; RhoGAP; GEF; B cells; MZ; WASp; BCR; primary immunodeficiencies; PC; autoimmunity; PE; FTY720