Simulation and analysis of cellular internalization pathways and membrane perturbation for graphene nanosheets

• Published in: Biomaterials Vol. 35; no. 23; pp. 6069 - 6077
• Main Authors: Mao, Jian, Guo, Ruohai, Yan, Li-Tang
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.07.2014
• Subjects: Advanced Basic Science; Animals; antibacterial properties; Biomedical materials; Cell membrane; Cell Membrane - chemistry; Cell Membrane - physiology; Cellular; Computer Simulation; cytotoxicity; Dentistry; Graphene; Graphite - chemistry; guidelines; Humans; lipid bilayers; Lipid Bilayers - chemistry; Membrane Fluidity - physiology; Membranes; Modeling; Models, Biological; Models, Chemical; Nanomaterials; Nanoparticles - chemistry; Nanoparticles - ultrastructure; nanosheets; Nanostructure; particle size; Pathways; physical phases; physicochemical properties; Simulation phase diagram; Surface Properties; Transmembrane transportation; Transmembrane transportation; Cell membrane; Graphene; Modeling; Simulation phase diagram

Clarifying the mechanisms of cellular interactions of graphene family nanomaterials is an urgent issue to the development of guidelines for safer biomedical applications and to the evaluation of health and environment impacts. By combining large-scale computer simulations, theoretical analysis, and...