Soluble cytokine receptors (sIL-2Rα, sIL-2Rβ) induce subunit-specific behavioral responses and accumulate in the cerebral cortex and basal forebrain

• Published in: PloS one Vol. 7; no. 4; p. e36316
• Main Authors: Zalcman, Steven S, Patel, Ankur, Mohla, Ruchika, Zhu, Youhua, Siegel, Allan
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 27.04.2012; Public Library of Science (PLoS)
• Subjects: Animals; B cells; Basal forebrain; Behavior disorders; Behavior, Animal - drug effects; Biology; Biomarkers; Body fluids; Brain; Brain research; c-Fos protein; Caudate-putamen; Cerebral cortex; Cerebral Cortex - drug effects; Cerebral Cortex - metabolism; Cytokine receptors; Cytokines; Disorders; Disturbances; Dopamine; Forebrain; Fos protein; Grooming; Head; Humans; Immunology; Interleukin 1; Interleukin 2; Interleukin-2 Receptor alpha Subunit - chemistry; Interleukin-2 Receptor alpha Subunit - metabolism; Interleukin-2 Receptor beta Subunit - chemistry; Interleukin-2 Receptor beta Subunit - metabolism; Interleukin-2 Receptor beta Subunit - pharmacology; Laboratories; Male; Medical research; Medical schools; Mental disorders; Mice; Mice, Inbred BALB C; Neostriatum; Neostriatum - drug effects; Neostriatum - metabolism; Neurons; Nucleus accumbens; Permeability; Prefrontal cortex; Proto-Oncogene Proteins c-fos - metabolism; Psychiatry; Putamen; Receptors; Recombinant Proteins - chemistry; Recombinant Proteins - metabolism; Recombinant Proteins - pharmacology; Rodents; Schizophrenia; Signal transduction; Solubility; Spools; Turning behavior; United States > US; New Jersey

Soluble cytokine receptors are normal constituents of body fluids that regulate peripheral cytokine and lymphoid activity. Levels of soluble IL-2 receptors (sIL-2R) are elevated in psychiatric disorders linked with autoimmune processes, including ones in which repetitive stereotypic behaviors and mo...