Significance of sphingosine kinase 1 expression in feline mammary tumors

• Published in: BMC veterinary research Vol. 15; no. 1; p. 155
• Main Authors: Chang, Yi-Chih, Chuang, Hsiao-Li, Yin, Ji-Hang, Liao, Jiunn-Wang, Chen, Ter-Hsin, Wang, Yu-Chih
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 17.05.2019; BioMed Central; BMC
• Subjects: Angiogenesis; animal tissues; Apoptosis; Breast cancer; breast neoplasms; Cancer; Cancer metastasis; Cancer treatment; Care and treatment; Cat diseases; cats; Cell survival; Cell viability; Ceramide; ceramides; Chemoresistance; Chemotherapy; Cytotoxicity; Diagnosis; Domestic cats; drug therapy; Enzymes; epithelial cells; estrogen receptors; Estrogens; Feline mammary tumor; Gastric cancer; Growth factors; Health aspects; histology; humans; Investigations; Kinases; Mammary gland; mammary glands; mammary neoplasms (animal); Medical prognosis; Metastases; Metastasis; Overexpression; Phenols (Class of compounds); Phosphates; Prognosis; Prostate cancer; Sphingosine; Sphingosine 1-phosphate; Sphingosine kinase; SPHK1 - comparative oncology; Therapeutic applications; Tumors; Veterinary oncology; China; SPHK1 - comparative oncology; Feline mammary tumor

Sphingosine kinase 1 (SPHK1) is an enzyme that converts pro-apoptotic ceramide and sphingosine into anti-apoptotic sphingosine-1-phosphate. There is growing evidence that SPHK1 activation promotes oncogenic transformation, tumor growth, chemotherapy resistance, and metastatic spread. High SPHK1 expr...