CTGA: the database for genetic disorders in Arab populations

The Arabs comprise a genetically heterogeneous group that resulted from the admixture of different populations throughout history. They share many common characteristics responsible for a considerable proportion of perinatal and neonatal mortalities. To this end, the Centre for Arab Genomic Studies...

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Published inNucleic acids research Vol. 34; no. 1; pp. D602 - D606
Main Authors Tadmouri, Ghazi O, Ali, Mahmoud Taleb Al, Ali, Sarah Al-Haj, Khaja, Najib Al
Format Journal Article
LanguageEnglish
Published England Oxford University Press 01.01.2006
Oxford Publishing Limited (England)
Subjects
Arabs
Arabs - genetics
Databases, Genetic
Genes
Genetic Diseases, Inborn - ethnology
Genetic Diseases, Inborn - genetics
genetic disorders
history
Humans
Internet
Internet resource
neonatal mortality
Phenotype
population genetics
User-Computer Interface
United Arab Emirates
Online AccessGet full text

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Abstract The Arabs comprise a genetically heterogeneous group that resulted from the admixture of different populations throughout history. They share many common characteristics responsible for a considerable proportion of perinatal and neonatal mortalities. To this end, the Centre for Arab Genomic Studies (CAGS) launched a pilot project to construct the 'Catalogue of Transmission Genetics in Arabs' (CTGA) database for genetic disorders in Arabs. Information in CTGA is drawn from published research and mined hospital records. The database offers web-based basic and advanced search approaches. In either case, the final search result is a detailed HTML record that includes text-, URL- and graphic-based fields. At present, CTGA hosts entries for 692 phenotypes and 235 related genes described in Arab individuals. Of these, 213 phenotypic descriptions and 22 related genes were observed in the Arab population of the United Arab Emirates (UAE). These results emphasize the role of CTGA as an essential tool to promote scientific research on genetic disorders in the region. The priority of CTGA is to provide timely information on the occurrence of genetic disorders in Arab individuals. It is anticipated that data from Arab countries other than the UAE will be exhaustively searched and incorporated in CTGA (http://www.cags.org.ae).
AbstractList The Arabs comprise a genetically heterogeneous group that resulted from the admixture of different populations throughout history. They share many common characteristics responsible for a considerable proportion of perinatal and neonatal mortalities. To this end, the Centre for Arab Genomic Studies (CAGS) launched a pilot project to construct the 'Catalogue of Transmission Genetics in Arabs' (CTGA) database for genetic disorders in Arabs. Information in CTGA is drawn from published research and mined hospital records. The database offers web-based basic and advanced search approaches. In either case, the final search result is a detailed HTML record that includes text-, URL- and graphic-based fields. At present, CTGA hosts entries for 692 phenotypes and 235 related genes described in Arab individuals. Of these, 213 phenotypic descriptions and 22 related genes were observed in the Arab population of the United Arab Emirates (UAE). These results emphasize the role of CTGA as an essential tool to promote scientific research on genetic disorders in the region. The priority of CTGA is to provide timely information on the occurrence of genetic disorders in Arab individuals. It is anticipated that data from Arab countries other than the UAE will be exhaustively searched and incorporated in CTGA (http://www.cags.org.ae).
The Arabs comprise a genetically heterogeneous group that resulted from the admixture of different populations throughout history. They share many common characteristics responsible for a considerable proportion of perinatal and neonatal mortalities. To this end, the Centre for Arab Genomic Studies (CAGS) launched a pilot project to construct the ‘Catalogue of Transmission Genetics in Arabs’ (CTGA) database for genetic disorders in Arabs. Information in CTGA is drawn from published research and mined hospital records. The database offers web-based basic and advanced search approaches. In either case, the final search result is a detailed HTML record that includes text-, URL- and graphic-based fields. At present, CTGA hosts entries for 692 phenotypes and 235 related genes described in Arab individuals. Of these, 213 phenotypic descriptions and 22 related genes were observed in the Arab population of the United Arab Emirates (UAE). These results emphasize the role of CTGA as an essential tool to promote scientific research on genetic disorders in the region. The priority of CTGA is to provide timely information on the occurrence of genetic disorders in Arab individuals. It is anticipated that data from Arab countries other than the UAE will be exhaustively searched and incorporated in CTGA ( ).
Author Ali, Mahmoud Taleb Al
Ali, Sarah Al-Haj
Khaja, Najib Al
Tadmouri, Ghazi O
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Copyright Copyright Oxford University Press(England) Jan 1, 2006
The Author 2006. Published by Oxford University Press. All rights reserved 2006
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To whom correspondence should be addressed. Tel: +971 4 398 6 777; Fax: +971 4 398 0 999; Email: tadmouri@hotmail.com, cags@emirates.net.ae
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References 15494797 - Saudi Med J. 2004 Oct;25(10):1331-6
10088038 - Ann Hum Genet. 1998 Sep;62(Pt 5):411-8
3777026 - Am J Med Genet. 1986 Oct;25(2):299-306
14643139 - Lancet. 2003 Nov 22;362(9397):1766
8131251 - Bull World Health Organ. 1994;72(1):145-54
8741908 - Am J Med Genet. 1996 Jan 2;61(1):1
15608251 - Nucleic Acids Res. 2005 Jan 1;33(Database issue):D514-7
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SubjectTerms Arabs
Arabs - genetics
Databases, Genetic
Genes
Genetic Diseases, Inborn - ethnology
Genetic Diseases, Inborn - genetics
genetic disorders
history
Humans
Internet
Internet resource
neonatal mortality
Phenotype
population genetics
User-Computer Interface
Title CTGA: the database for genetic disorders in Arab populations
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