Triglyceride-Rich Lipoprotein Modulates Endothelial Vascular Cell Adhesion Molecule (VCAM)-1 Expression via Differential Regulation of Endoplasmic Reticulum Stress

• Published in: PloS one Vol. 8; no. 10; p. e78322
• Main Authors: Wang, Ying I., Bettaieb, Ahmed, Sun, Chongxiu, DeVerse, J. Sherrod, Radecke, Christopher E., Mathew, Steven, Edwards, Christina M., Haj, Fawaz G., Passerini, Anthony G., Simon, Scott I.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 21.10.2013; Public Library of Science (PLoS)
• Subjects: Adhesion; Aorta; Apoptosis; Atherosclerosis; Atherosclerosis - genetics; Atherosclerosis - metabolism; Biomedical engineering; Blood lipids; Cardiovascular diseases; CCAAT/enhancer-binding protein; Cell adhesion; Cell adhesion & migration; Cell adhesion molecules; Cells, Cultured; Cholesterol; Correlation; Down-Regulation - genetics; Endocrinology; Endoplasmic reticulum; Endoplasmic Reticulum - genetics; Endoplasmic Reticulum - metabolism; Endoplasmic Reticulum Stress - genetics; Endothelial cells; Endothelial Cells - metabolism; Endothelium; Endothelium, Vascular - metabolism; Engineering; Fatty acids; Female; Gene Expression Regulation - genetics; Gene regulation; Health risks; Homeostasis; Homology; Humans; Infiltration; Inflammation; Initiation factor eIF-2α; Inositol; Insulin resistance; Interferon; Interferon regulatory factor; Interferon regulatory factor 1; Internalization; Kinases; Lipids; Lipoproteins; Lipoproteins - genetics; Lipoproteins - metabolism; Low density lipoprotein receptors; Male; Metabolism; Metastases; Monocytes; Monocytes - metabolism; Nutrition; Obesity; Phenylbutyric acid; Protein binding; Protein folding; Proteins; Regulations; Sensors; siRNA; Sterols; Stimulation; Stress; Stress response; Stresses; Transcription factors; Triglycerides; Triglycerides - genetics; Triglycerides - metabolism; Tumor necrosis factor; Tumor Necrosis Factor-alpha - genetics; Tumor Necrosis Factor-alpha - metabolism; Tumor necrosis factor-TNF; Tumor necrosis factor-α; Type 2 diabetes; Unfolded Protein Response - genetics; Up-Regulation - genetics; Vascular cell adhesion molecule 1; Vascular Cell Adhesion Molecule-1 - genetics; Vascular Cell Adhesion Molecule-1 - metabolism; United States > US; California

Circulating triglyceride-rich lipoproteins (TGRL) from hypertriglyceridemic subjects exacerbate endothelial inflammation and promote monocyte infiltration into the arterial wall. We have recently reported that TGRL isolated from human blood after a high-fat meal can elicit a pro- or anti-atherogenic...