APEX Nuclease (Multifunctional DNA Repair Enzyme) 1 Gene Asp148Glu Polymorphism and Cancer Risk: A Meta-Analysis Involving 58 Articles and 48903 Participants

• Published in: PloS one Vol. 8; no. 12; p. e83527
• Main Authors: Hu, Dan, Lin, Xiandong, Zhang, Hejun, Zheng, Xiongwei, Niu, Wenquan
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 12.12.2013; Public Library of Science (PLoS)
• Subjects: Amino Acid Substitution; Bias; Bladder cancer; Cancer; Cancer genetics; Carcinogenesis; Carcinogens; Colorectal cancer; Confidence intervals; Data processing; Deoxyribonucleic acid; Development and progression; DNA; DNA repair; DNA-(Apurinic or Apyrimidinic Site) Lyase - genetics; Enzymes; Estimates; Female; Gastric cancer; Gene polymorphism; Genes; Genetic aspects; Genetic polymorphisms; Genomics; Genotype & phenotype; Health aspects; Health risks; Heterogeneity; Humans; Laboratories; Lung cancer; Male; Medical ethics; Medical prognosis; Medicine; Meta-analysis; Minority & ethnic groups; Mutation; Mutation, Missense; Neoplasm Proteins - genetics; Nuclease; Pathology; Polymorphism; Polymorphism, Genetic; Population; Population studies; Prostate cancer; Regression analysis; Repair; Risk analysis; Risk Factors; Statistical analysis; Stomach cancer; Stomach Neoplasms - genetics; Studies; Teaching hospitals; China

Polymorphisms in the APEX nuclease (multifunctional DNA repair enzyme) 1 gene (APEX1) may be involved in the carcinogenesis by affecting DNA repair. We aimed to summarize available data on the association of the APEX1 Asp148Glu (rs1130409) polymorphism with risk of multiple types of cancer via a met...