Genome-wide approaches to studying chromatin modifications

• Published in: Nature reviews. Genetics Vol. 9; no. 3; pp. 179 - 191
• Main Authors: Schones, Dustin E., Zhao, Keji
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.03.2008; Nature Publishing Group
• Subjects: Agriculture; Animal Genetics and Genomics; Animals; Antibodies; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Cancer Research; Chromatin - metabolism; Chromatin. Chromosome; DNA Methylation; Enzymes; Epigenesis, Genetic; Epigenetics; Fundamental and applied biological sciences. Psychology; Gene expression; Gene Function; Genome; Genomes; Genomics; Histone Code; Human Genetics; Humans; Molecular and cellular biology; Molecular genetics; Proteins; review-article; Epigenetics; Chromosome; Chromatin; Nucleosome

Key Points Chromatin modifications have been shown to have a profound impact on the regulation of gene expression. Epigenomes consist of the ensemble of all chromatin modifications in any given cell type, including DNA methylation, post-translational histone modifications, nucleosome positioning, hi...