Role of decreased androgens in the ovarian response to stimulation in older women

• Published in: Fertility and sterility Vol. 99; no. 1; pp. 5 - 11
• Main Authors: Meldrum, David R., Chang, R. Jeffrey, Giudice, Linda C., Balasch, Juan, Barbieri, Robert L.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2013
• Subjects: Adult; Age; Aging - physiology; Androgens - metabolism; animal ovaries; Chorionic Gonadotropin - pharmacology; controlled ovarian hyperstimulation; Female; Gonadotropins - pharmacology; growth hormone; human chorionic gonadotropin; Humans; IGF-I; insulin; Insulin - metabolism; insulin-like growth factor I; Insulin-Like Growth Factor I - metabolism; Internal Medicine; luteinizing hormone; Luteinizing Hormone - pharmacology; Middle Aged; Obstetrics and Gynecology; oocytes; Oocytes - cytology; Oocytes - drug effects; Oocytes - metabolism; Ovarian Follicle - drug effects; Ovarian Follicle - physiology; Ovulation Induction; somatotropin; testosterone; Testosterone - metabolism; Testosterone - pharmacology; unspecific monooxygenase; women; IGF-I; growth hormone; testosterone; controlled ovarian hyperstimulation; female; Age

Ovarian testosterone increases the response of antral follicles to stimulation, declines with age, and has effects mediated or potentiated by insulin-like growth hormone I (IGF-I). Increased circulating insulin and IGF-I, exogenous testosterone, and increased local ovarian testosterone concentration...