PEGylated PAMAM dendrimer–doxorubicin conjugate-hybridized gold nanorod for combined photothermal-chemotherapy

• Published in: Biomaterials Vol. 35; no. 24; pp. 6576 - 6584
• Main Authors: Li, Xiaojie, Takashima, Munenobu, Yuba, Eiji, Harada, Atsushi, Kono, Kenji
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.08.2014
• Subjects: Advanced Basic Science; Animals; Antineoplastic Agents - therapeutic use; chemical bonding; Chemotherapy; confocal laser scanning microscopy; Dendrimer; dendrimers; Dendrimers - chemical synthesis; Dendrimers - chemistry; Dentistry; Doxorubicin; Doxorubicin - pharmacology; Doxorubicin - therapeutic use; drug therapy; Female; fever; Gold - chemistry; Gold nanorods; HeLa Cells; Humans; Hyperthermia, Induced; Light; lysosomes; Mice, Inbred BALB C; Microscopy, Fluorescence; nanogold; nanorods; Nanotubes - chemistry; Nanotubes - ultrastructure; neoplasm cells; neoplasms; Phototherapy; Photothermal therapy; polyethylene glycol; Polyethylene Glycols - chemical synthesis; Polyethylene Glycols - chemistry; Scattering, Radiation; Photothermal therapy; Dendrimer; Chemotherapy; Gold nanorods; Doxorubicin

We prepared pH-sensitive drug–dendrimer conjugate-hybridized gold nanorod as a promising platform for combined cancer photothermal-chemotherapy under in vitro and in vivo conditions. Poly(ethylene glycol)-attached PAMAM G4 dendrimers (PEG–PAMAM) were first covalently linked on the surface of mercapt...