Reduced blood pressure in sickle cell disease is associated with decreased angiotensin converting enzyme (ACE) activity and is not modulated by ACE inhibition

• Published in: PloS one Vol. 17; no. 2; p. e0263424
• Main Authors: Brito, Pamela L., dos Santos, Alisson F., Chweih, Hanan, Favero, Maria E., Gotardo, Erica M. F., Silva, Juliete A. F., Leonardo, Flavia C., Franco-Penteado, Carla F., de Oliveira, Mariana G., Ferreira, Wilson A., Zaidan, Bruna C., Billis, Athanase, Baldanzi, Giorgio, Mashima, Denise A., Antunes, Edson, Saad, Sara T. Olalla, Costa, Fernando F., Conran, Nicola
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 03.02.2022; Public Library of Science (PLoS)
• Subjects: Adolescent; Adult; Anemia, Sickle Cell - drug therapy; Anemia, Sickle Cell - physiopathology; Angiotensin; Angiotensin converting enzyme; Angiotensin II; Angiotensin II - metabolism; Angiotensin-Converting Enzyme Inhibitors - pharmacology; Animal models; Animals; Biology and Life Sciences; Blood pressure; Blood Pressure - drug effects; Complications and side effects; Conversion; Damage; Depletion; Diastole; Disease Models, Animal; Enzymatic activity; Enzyme activity; Enzymes; Ethics; Female; Health aspects; Hematology; Hemoglobin; Humans; Hydroxyurea - pharmacology; Hypotension; Immunoassay; Kidneys; Laboratory animals; Male; Medicine and Health Sciences; Mice; Mice, Inbred C57BL; Middle Aged; Nephropathy; Organs; Patients; Peptides; Peptidyl-dipeptidase A; Peptidyl-Dipeptidase A - biosynthesis; Real-Time Polymerase Chain Reaction; Renin; Renin - blood; Renin-Angiotensin System; Research and Analysis Methods; Sickle cell anemia; Sickle cell disease; Systole; Transplants & implants; Young Adult; Brazil

Sickle cell disease (SCD) incurs vaso-occlusive episodes and organ damage, including nephropathy. Despite displaying characteristics of vascular dysfunction, SCD patients tend to present relatively lower systemic blood pressure (BP), via an unknown mechanism. We investigated associations between BP...